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Antimutagenic Effect of the Fruiting Body and the Mycelia Extracts of Coprinus comatus
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먹물버섯 자실체 및 균사체 추출물의 돌연변이 억제효과

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Academic journal
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The korean Society of Food Science and Nutrition Journal of the Korean Society of Food Science and Nutrition Vol.28 No.2 KCI Accredited Journals SCOPUS
Published
1999.4
Pages
452 - 457 (6page)

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Antimutagenic Effect of the Fruiting Body and the Mycelia Extracts of Coprinus comatus
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The inhibitory effect of Coprinus comatus on the mutagenicity in Salmonella assay system and SOS chromotest were studied. In Ames test, the ethanol and water extracts and the cultured mycelia fractions of Coprinus comatus did not show any mutagenicity, but the Coprinus comatus ethanol extracts showed inhibitory effects of 80~90% on the mutagenicity induced by indirect mutagen of benzo(a)pyrene(B(a)P) and aflatoxin B₁(AFB₁) in Salmonella typhimurium TA98 and TA100. The antimutagenic effect increased with increasing concentration of the ethanol extract toward N-methyl-N′-nitro-N-nitrosoguanidine(MNNG). However, the water extracts inhibited about 40~50% against direct and indirect mutagen. The cultured mycelial filtrate of Coprinus comatus, the fraction Ⅱ, showed antimutagenic effect of 90% on MNNG and 25~50% on B(a)P and AFB₁. In SOS chromotest, the ethanol extracts of Coprinus comatus showed antimutagenic effect of 65~81% on SOS function induced by 4-NQO, and the cultured mycelia fraction Ⅱ showed low inhibitory effect of 20~50%.

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