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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Previous studies have demonstrated that expression of galectin-3, a member of family of beta-galactosidebinding animal lectin, is associated with pathological conditions including cancer, atherosclerosis, and viral infection. An increase of this lectin has been observed after infection by Kirsten murine sarcoma, human T lymphotropic virus-1 (HTLV-1), and human immunodeficiency virus-1 (HIV-1). Viral transactivation protein Tax of HTLV-1 mediates the increase in the lectin. In case of HIV-1, there are evidences that Tat would be related with increase in galectin-3. We investigated whether Tat directly induced galectin-3 expression in cells. We found that HIV-1 tat gene activated galectin-3 promoter in RAW264.7 cells. To demonstrate direct induction of galectin-3 by HIV-1 tat, we transfected the tat into a rabbit smooth muscle cell line (Rb1) and obtained Rb1TatCl-2, a clone of cell stably transfected with tat gene. The Rb1TatCl-2 cells exhibited activation of LTR promoter and up-regulation of galectin-3 transcript as well as protein. Our results indicate that HIV-1 tat alone is sufficient to induce the expression of galectin-3. The Rb1TatCl-2 cells could be valuable for study of the effect of HIV-1 tat on expression of cellular genes.
목차
Abstract
Materials and Methods
Results
Discussion
ACKNOWLEDGMENT
References
참고문헌 (32)
참고문헌 신청
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Akahani, S., P. Nangia-Makker, H. Inohara, H. R. Kim and A. Raz. 1997. Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family. Cancer Res. 57, 5272-5276.
Albini, A., R. Soldi, D. Giunciuglio, E. Giraudo, R. Benelli, L. Primo, D. Noonan, M. Salio, G. Camussi, W. Rockl and F. Bussolino. 1996. The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells. Na
Barondes, S. H., D. N. W. Cooper, M. A. Gitt and H. Leffler. 1994. Galectins. Structure and function of a large family of animal lectins. J. Biol. Chem. 269, 20807-20810.
Buonaguro, L., G. Barillari., H. K. Chang, C. A. Bohan, V. Kao, R. Morgan, R. C. Gallo and B. Ensoli. 1992. Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines. J. Virol. 66, 7159-7167.
Akahani, S., P. Nangia-Makker, H. Inohara, H. R. Kim and A. Raz. 1997. Galectin-3: a novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family. Cancer Res. 57, 5272-5276.
Albini, A., R. Soldi, D. Giunciuglio, E. Giraudo, R. Benelli, L. Primo, D. Noonan, M. Salio, G. Camussi, W. Rockl and F. Bussolino. 1996. The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells. Na
Barondes, S. H., D. N. W. Cooper, M. A. Gitt and H. Leffler. 1994. Galectins. Structure and function of a large family of animal lectins. J. Biol. Chem. 269, 20807-20810.
Buonaguro, L., G. Barillari., H. K. Chang, C. A. Bohan, V. Kao, R. Morgan, R. C. Gallo and B. Ensoli. 1992. Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines. J. Virol. 66, 7159-7167.
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UCI(KEPA) : I410-ECN-0101-2009-470-015374737