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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.9
- 수록면
- 161 - 168 (8page)
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초록· 키워드
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Salicornia herbacea L. (Chenopodiaceae: S. herbacea) is a salt marsh plant, which has long been prescribed in traditional medicines for the treatment of intestinal ailments, nephropathy, and hepatitis in Oriental countries. In order to elucidate the mechanisms of this herb, we conducted an anti-oxidative activity, the inhibition of nitric oxide (NO) production, and the suppression of the pro-inflammatory cytokine genes, with the solvent-extracts of S. herbacea. We found that both ethyl acetate and n-butanol fractions showed potent anti-oxidative effects in comparison to other fractions using xanthine oxidase assay with IC50 values of 66.0±0.5 ㎍/㎖ and 82.5±3.8 ㎍/㎖, respectively. In addition, both ethyl acetate and n-butanol fractions showed more electron donating activity (EDA) than other fractions, according to DPPH (2, 2-Diphenyl-lpicrylhydrazyl radical) assay. The EDA of ethyl acetate fraction (IC50 values of 117.5±3.8 ㎍/㎖) is more significant than that of n-butanol fraction (IC50 values of 375.0±12.5 ㎍/㎖). Among potential anti-oxidative fractions, ethyl acetate fraction dose-dependently suppressed lipopolysaccharide (LPS, 0.1 ㎍/㎖)-induced nitric oxide (NO) production in RAW264.7 cell, while n-butanol did not. As expected, ethyl acetate fraction suppressed the expression of inducible NO synthase (iNOS) in RAW264.7 cell stimulated by 0.1 ㎍/㎖ of LPS. Moreover, the ethyl acetate fraction suppressed the expression of interleukin-1 (IL)-1β and granulocyte/macrophage colony-stimulating factor (GM-CSF) mRNA in LPS-stimulated RAW264.7 cells. Therefore, these results suggest that S. herbacea may have anti-oxidative and anti-inflammatory activities by modulating radical-induced toxicity and various pro-inflammatory responses.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
Acknowledgements
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2009-510-015971259