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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Journal of Food Science and Nutrition Journal of Food Science and Nutrition Vol.13 No.2
- 발행연도
- 2008.6
- 수록면
- 84 - 89 (6page)
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초록· 키워드
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This study was designed to investigate the protective effect of a methanol extract of Chungkookjang (CKJ) on high glucose induced oxidative stress in LLC-PK₁ cells (renal tubular epithelial cells), which are susceptible to oxidative stress. Freeze dried CKJ powder was extracted with methanol, and the extract solution was concentrated, and then used in this study. To determine the protective effect of CKJ extract, oxidative stress was induced by exposing of LLC-PK₁ cells to high glucose (30 mM) or normal glucose (5 mM) for 24 hr. Exposure of LLC-PK₁ cells to high glucose for 24 hr resulted in a significant (p＜0.05) decrease in cell viability, catalase, SOD and GSH-px activity and a significant (p＜0.05) increase in intracellular ROS level and thiobarbituric acid reactive substances (TBARS) formation in comparison to the cells treated with 5 mM glucose. CKJ extract treatment decreased intracellular ROS level and TBARS formation, and increased cell viability and activities of antioxidant enzymes including catalase, SOD and GSH-px in high glucose pretreated LLC-PK₁ cells. These results suggest that CKJ extract may be able to protect LLC-PK₁ cells from high glucose-induced oxidative stress, partially through the antioxidative defense systems.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (46)
참고문헌 신청
1. [학술지(정기간행물)] - Willcox JK / 2004 / Antioxidants and prevention of chronic disease / Crit Rev Food Sci Nutr 44 : 275 ~ 295
2. [학술지(정기간행물)] - Kawanish S / 2005 / The role of metals in site-specific DNA damage with reference to carcinogenesis / Free Radic Biol Med 32 : 822 ~ 832
3. [학술지(정기간행물)] - Sachidanandame K / 2005 / Oxidative stress and cardiovascular disease: Antioxidants and unresolved issues / Cardiovasc Drug Rev 23 : 115 ~ 132
4. [학술지(정기간행물)] - Kim KS / 2003 / Anti-oxidant activities of the extracts from the hurbs of Artemisia apiacea / J Ethnopharmacol 85 : 69 ~ 72
5. [학술지(정기간행물)] - Hou YZ / 2004 / Protective effect of Ligusticum chuanxiong and Angelica sinensis on endothelial cell damage induced by hydrogen peroxide / Life Sci 75 : 1775 ~ 1786
2. [학술지(정기간행물)] - Kawanish S / 2005 / The role of metals in site-specific DNA damage with reference to carcinogenesis / Free Radic Biol Med 32 : 822 ~ 832
3. [학술지(정기간행물)] - Sachidanandame K / 2005 / Oxidative stress and cardiovascular disease: Antioxidants and unresolved issues / Cardiovasc Drug Rev 23 : 115 ~ 132
4. [학술지(정기간행물)] - Kim KS / 2003 / Anti-oxidant activities of the extracts from the hurbs of Artemisia apiacea / J Ethnopharmacol 85 : 69 ~ 72
5. [학술지(정기간행물)] - Hou YZ / 2004 / Protective effect of Ligusticum chuanxiong and Angelica sinensis on endothelial cell damage induced by hydrogen peroxide / Life Sci 75 : 1775 ~ 1786
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