지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 327 - 333 (7page)
이용수
초록· 키워드
오류제보하기
Heterotrimeric GTP binding proteins, G-proteins, mediate signal transduction generated by neurotransmitters and hormones. Among G-proteins, Go proteins are the most abundant in brain and classified as a member of Gi family. Ras-like protein in all tissues (Rit), one of the small GTPases, is a member of a Ras superfamily and identified as an important regulator of neuronal differentiation and cell transformation. Recently, we have reported that Rit functioned as a candidate downstream effector for alpha subunit of Go proteins (Goα) and regulated neurite outgrowth triggered by Goα activation. In this study, we showed that the GTPase domain of Goα contributed to the direct interaction with Rit. We also demonstrated that Goα could lead to an increase of Rit activity suggesting that Rit play a role as a downstream effector of Goα.
목차
서론
재료 및 방법
결과 및 고찰
감사의 글
REFERENCES
참고문헌 (37)
참고문헌 신청
1. [학술지(정기간행물)] - Beltramo M / 2006 / CB2 receptor-mediated antihyperalgesia: possible direct involvement of neural mechanisms / Eur J Neurosci 23 : 1530 ~ 1538
2. [학술지(정기간행물)] - Birnbaumer L / 1992 / Receptor-to-effector signaling through G proteins: roles for beta gamma dimers as well as alpha subunits / Cell 71 : 1069 ~ 1072
3. [학술지(정기간행물)] - Bivona TG / 2004 / Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion / J Cell Biol 164 : 461 ~ 470
4. [학술지(정기간행물)] - Coleman DE / 1994 / Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis / Science 265 : 1405 ~ 1412
5. [학술지(정기간행물)] - Doherty P / 1991 / Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L- and N-type neuronal Ca2+ channels / Cell 67 : 21 ~ 33
2. [학술지(정기간행물)] - Birnbaumer L / 1992 / Receptor-to-effector signaling through G proteins: roles for beta gamma dimers as well as alpha subunits / Cell 71 : 1069 ~ 1072
3. [학술지(정기간행물)] - Bivona TG / 2004 / Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion / J Cell Biol 164 : 461 ~ 470
4. [학술지(정기간행물)] - Coleman DE / 1994 / Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis / Science 265 : 1405 ~ 1412
5. [학술지(정기간행물)] - Doherty P / 1991 / Morphoregulatory activities of NCAM and N-cadherin can be accounted for by G protein-dependent activation of L- and N-type neuronal Ca2+ channels / Cell 67 : 21 ~ 33
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UCI(KEPA) : I410-ECN-0101-2010-510-001689994