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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.12
- 수록면
- 405 - 411 (7page)
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Heterotrimeric GTP binding proteins (G proteins) mediate signal transduction generated by neurotransmitter and hormones. Among G-proteins, Go is classified as a member of the Go/Gi family and the most abundant heterotrimeric G protein in brain. Most of the mechanistic analyses on the activation of Go indicated its action to be mediated by the Gβγ dimer because downstream effectors for its α subunit have not been clearly defined. To determine the downstream effectors of alpha subunits of Go (Goα), we used yeast two-hybrid system to screen Goα interacting partners in cDNA library from the human brain. A brain specific high mobility group box containing protein (BHX), A possible transcription factor, was identified as a Goα interacting protein. We confirmed interaction between Goα and BHX employing in vitro affinity binding assay. Moreover, active form of Goα preferentially interacts with BHX than inactive form. Our findings indicate that Goα could modulate gene expression via interaction with BHX during neuronal or brain development.
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UCI(KEPA) : I410-ECN-0101-2009-510-017674002