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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 167 - 172 (6page)
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초록· 키워드
오류제보하기
An 1-year-long clinical study on Estromon<SUP>®</SUP>, a combinational regimen composed of FGF271 (a mixture extract of 3 herbs; Cynanchum wilfordii, Angelica gigas, Phlomis umbrosa), amino acids, vitamins and minerals, reported a significant effectiveness in the improvement of menopausal symptoms including vaginal dryness and hot flush, serum osteocalcin level and bone mineral density (BMD) of femoral bone. In the present studies, alkaline phosphatase (ALP)-inducing and anti-menopausal effects of FGF271 were investigated in vitro and in vivo, respectively, in comparison with Estromon<SUP>®</SUP>. In vitro study, FGF271 was superior to its ingredient herbal extracts, Cynanchum wilfordii, Angelica gigas and Phlomis umbrosa, in the induction of estrogen-specific ALP in Ishikawa and SaOS-2 cells. In ovariectomized animals, oral administration of FGF271 (100 ㎎/㎏) for 12 weeks significantly (P＜0.05) recovered the decreased BMD following ovariectomy, in which the effect of FGF271 was higher than that of Estromon<SUP>®</SUP> (100 ㎎/㎏). On the contrary, treatment of SoyLife<SUP>®</SUP> (100 ㎎/㎏) containing 40% isoflavones did not exert significant beneficial effects. In conclusion, it was confirmed that the 3 herbal extracts, ingredients of FGF271, exhibit additive or synergistic phytoestrogenic activities, and that the anti-menopausal effects of Estromon<SUP>®</SUP> are attributed to FGF271.
목차
재료 및 방법
결과 및 고찰
Acknowledgment
References
참고문헌 (26)
참고문헌 신청
Alonso, A , 2007 , Leptin and its receptor are controlled by 17beta-estradiol in peripheral tissues of ovariectomized rats , Exp. Biol. Med. (Maywood) 232 (4) : 542 ~ 549
Clarke, A.P , 1992 , Targeted estrogen, progesterone replacement therapy for osteoporosis: calculation of health care cost savings , Osteoporosis Int 2 : 195 ~ 200
Clegg, D.J , 2006 , Gonadal hormones determine sensitivity to central leptin and insulin , Diabetes 55 (4) : 978 ~ 987
Cummings, S.R , 1990 , The future of hip fractures in the United States: numbers, costs and potential effects of postmenopausal estrogen , Clin. Orthoped. Related Res 252 : 163 ~ 166
Elfituri, A , 2005 , Two hormone replacement therapy (HRT) regimens for middleeastern postmenopausal women , Maturitas 52 (1) : 52 ~ 59
Clarke, A.P , 1992 , Targeted estrogen, progesterone replacement therapy for osteoporosis: calculation of health care cost savings , Osteoporosis Int 2 : 195 ~ 200
Clegg, D.J , 2006 , Gonadal hormones determine sensitivity to central leptin and insulin , Diabetes 55 (4) : 978 ~ 987
Cummings, S.R , 1990 , The future of hip fractures in the United States: numbers, costs and potential effects of postmenopausal estrogen , Clin. Orthoped. Related Res 252 : 163 ~ 166
Elfituri, A , 2005 , Two hormone replacement therapy (HRT) regimens for middleeastern postmenopausal women , Maturitas 52 (1) : 52 ~ 59
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UCI(KEPA) : I410-ECN-0101-2009-510-014843974