지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.12
- 수록면
- 1,131 - 1,138 (8page)
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초록· 키워드
오류제보하기
Diabetic complications are a leading cause of blindness, renal failure, and nerve damage. Additionally, diabetesaccelerated atherosclerosis leads to increased risk of myocardial infarction, stroke, and limb amputation. At the present time, 4 main molecular mechanisms have been implicated in hyperglyceamia-mediated vascular damage. In particular, advanced glycation endproducts (AGE), which are formed by complex, heterogeneous, sugar-derived protein modifications, have been implicated as a major pathogenic process for diabetic complications. Recently, AGE inhibitors such as aminoguanidin, ALT-946, and pyridoxamine have been reported. Such an integrating paradigm provides a new conceptual framework for future research on diabetes complications and on discovering drugs to prevent the progression of AGE-induced maladies.
목차
Abstract
Introduction
Mechanisms of Diabetic Complications
AGEs and Diabetic Complications
Formation of Various AGEs in vivo and Related Toxicity
AGE Formation During Diabetic Conditions
ROS and Diabetes
Pharmacological Inhibition of AGEs
Conclusion
Acknowledgments
References
참고문헌 (73)
참고문헌 신청
1. [학술지(정기간행물)] - Evans E / 2004 / Management of gestational diabetes mellitus and pharmacists' role in patient education / Am. J. Health-Syst. Ph 61 : 1460 ~ 1465
2. [학술지(정기간행물)] - Argoff CE / 2006 / Diabetic peripheral neuropathic pain: Clinical and quality-of-life issues / Mayo Clin. Proc 81 : 3 ~ 11
3. [학술지(정기간행물)] - Sarti C / 2006 / The metabolic syndrome: Prevalence, CHD risk, and treatment / J. Diabetes Complicat 20 : 121 ~ 132
4. [학술지(정기간행물)] - Somoza V / 2005 / Five years of research on health risks and benefits of Maillard reaction products: An update / Mol. Nutr. Food Res 49 : 663 ~ 672
5. [학술지(정기간행물)] - Bierhaus A / 1998 / AGEs and their interactions with AGE receptors in vascular disease and diabetes mellitus: AGE concept / Cardiovasc. Res 37 : 586 ~ 600
2. [학술지(정기간행물)] - Argoff CE / 2006 / Diabetic peripheral neuropathic pain: Clinical and quality-of-life issues / Mayo Clin. Proc 81 : 3 ~ 11
3. [학술지(정기간행물)] - Sarti C / 2006 / The metabolic syndrome: Prevalence, CHD risk, and treatment / J. Diabetes Complicat 20 : 121 ~ 132
4. [학술지(정기간행물)] - Somoza V / 2005 / Five years of research on health risks and benefits of Maillard reaction products: An update / Mol. Nutr. Food Res 49 : 663 ~ 672
5. [학술지(정기간행물)] - Bierhaus A / 1998 / AGEs and their interactions with AGE receptors in vascular disease and diabetes mellitus: AGE concept / Cardiovasc. Res 37 : 586 ~ 600
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UCI(KEPA) : I410-ECN-0101-2013-573-000858236