지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.8
- 수록면
- 928 - 931 (4page)
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초록· 키워드
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Effects of perilla leaf extracts (PLE) on adipocytes differentiation of 3T3-L1 cells were examined. Ethanol extract of PLE treatment significantly decreased lipid accumulation, a marker of adipogenesis, in a dose-dependent manner. Moreover, gene expression levels of peroxisome proliferator-activated receptor γ (PPARγ), the key adipogenic transcription factor, were markedly decreased by PLE. PLE also suppressed adipocyte fatty acid binding protein (aP2) and glycerol-3-phosphate dehydrogenase (GPDH), which are adipogenic marker proteins. These results suggest that PLE treatment suppressed differentiation of 3T3-L1 adipocytes, in part by down-regulating expression of adipogenic transcription factor and other specific target genes.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Acknowledgments
References
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Fruhbeck G / 2001 / The adipocyte: A model for integration of endocrine and metabolic signaling in energy metabolism regulation / Am. J. Physiol. -Endoc. M 280 : E827 ~ E847
2. [학술지(정기간행물)] - Izem L / 2007 / Possible role for intracellular cholesteryl ester transfer protein in adipocyte lipid metabolism and storage / J. Biol. Chem. 282 : 21856 ~ 21865
3. [학술지(정기간행물)] - Sharma AM / 2002 / Adipose tissue: A mediator of cardiovascular risk / Int.J. Obesity 26 : S5 ~ S7
4. [학술지(정기간행물)] - Kawada T / 2001 / Biochemical and physiological characteristics of fat cell / J. Nutr. Sci. Vitaminol. 47 : 1 ~ 12
5. [학술지(정기간행물)] - Lehmann JM / 1995 / An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPARγ) / J. Biol. Chem. 270 : 12953 ~ 12956
2. [학술지(정기간행물)] - Izem L / 2007 / Possible role for intracellular cholesteryl ester transfer protein in adipocyte lipid metabolism and storage / J. Biol. Chem. 282 : 21856 ~ 21865
3. [학술지(정기간행물)] - Sharma AM / 2002 / Adipose tissue: A mediator of cardiovascular risk / Int.J. Obesity 26 : S5 ~ S7
4. [학술지(정기간행물)] - Kawada T / 2001 / Biochemical and physiological characteristics of fat cell / J. Nutr. Sci. Vitaminol. 47 : 1 ~ 12
5. [학술지(정기간행물)] - Lehmann JM / 1995 / An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPARγ) / J. Biol. Chem. 270 : 12953 ~ 12956
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UCI(KEPA) : I410-ECN-0101-2013-573-000874734