지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.10
- 수록면
- 262 - 266 (5page)
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초록· 키워드
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Purpose: Adequate lymph node analysis is critical for appropriate staging in colorectal cancer. The aim of this study is to determine whether 12 or more nodes recovered in stage Ⅲ rectal cancer results in improved oncologic outcomes.
Methods: Two hundred and forty-eight patients with stage Ⅲ rectal cancer from 1995 through 2004 were reviewed. They were categorized into 2 subgroups by the number of nodes retrieved (＜12 and ≥12), and oncologic outcomes in terms of 5-year overall and disease-free survival were analyzed for all patients, patients with American Joint Committee on Cancer (AJCC) N1 disease (N=145), and those with AJCC N2 (N=103).
Results: Five-year overall and disease-free survival was 79.0% and 58.4%, respectively. There was no significant difference in clincopathologic features between ＜12 retrieval group and ≥12 group. Although there was significant difference in overall survival and disease-free survival between the number (＜12 and ≥12) of lymph nodes removed in N2 disease (P=0.043; P=0.022) in univariate analysis, the total number of lymph nodes retrieved was not a prognostic factor affecting survival in multivariate analysis. The N2 stage and lateral margin involvement were prognostic factors affecting survival in multivariate analysis.
Conclusion: This study showed that the total number of lymph nodes analyzed for stage Ⅲ rectal cancer is not a prognostic factor on overall or disease-free survival in multivariate analysis.
Methods: Two hundred and forty-eight patients with stage Ⅲ rectal cancer from 1995 through 2004 were reviewed. They were categorized into 2 subgroups by the number of nodes retrieved (＜12 and ≥12), and oncologic outcomes in terms of 5-year overall and disease-free survival were analyzed for all patients, patients with American Joint Committee on Cancer (AJCC) N1 disease (N=145), and those with AJCC N2 (N=103).
Results: Five-year overall and disease-free survival was 79.0% and 58.4%, respectively. There was no significant difference in clincopathologic features between ＜12 retrieval group and ≥12 group. Although there was significant difference in overall survival and disease-free survival between the number (＜12 and ≥12) of lymph nodes removed in N2 disease (P=0.043; P=0.022) in univariate analysis, the total number of lymph nodes retrieved was not a prognostic factor affecting survival in multivariate analysis. The N2 stage and lateral margin involvement were prognostic factors affecting survival in multivariate analysis.
Conclusion: This study showed that the total number of lymph nodes analyzed for stage Ⅲ rectal cancer is not a prognostic factor on overall or disease-free survival in multivariate analysis.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (21)
참고문헌 신청
1. [학술지(정기간행물)] - Greene FL / 2002 / A new TNM staging strategy for node-positive (stage III) colon cancer: an analysis of 50,042 patients / Ann Surg 236 : 416 ~ 421
2. [학술지(정기간행물)] - Compton CC / 2004 / The staging of colorectal cancer: 2004 and beyond / CA Cancer J Clin 54 : 295 ~ 308
3. [학술지(정기간행물)] - Sarli L / 2005 / Number of lymph nodes examined and prognosis of TNM stage II colorectal cancer / Eur J Cancer 41 : 272 ~ 279
4. [학술지(정기간행물)] - Joseph NE / 2003 / Accuracy of determining nodal negativity in colorectal cancer on the basis of the number of nodes retrieved on resection / Ann Surg Oncol 10 : 213 ~ 218
5. [학술지(정기간행물)] - Law CH / 2003 / Impact of lymph node retrieval and pathological ultra-staging on the prognosis of stage II colon cancer / J Surg Oncol 84 : 120 ~ 126
2. [학술지(정기간행물)] - Compton CC / 2004 / The staging of colorectal cancer: 2004 and beyond / CA Cancer J Clin 54 : 295 ~ 308
3. [학술지(정기간행물)] - Sarli L / 2005 / Number of lymph nodes examined and prognosis of TNM stage II colorectal cancer / Eur J Cancer 41 : 272 ~ 279
4. [학술지(정기간행물)] - Joseph NE / 2003 / Accuracy of determining nodal negativity in colorectal cancer on the basis of the number of nodes retrieved on resection / Ann Surg Oncol 10 : 213 ~ 218
5. [학술지(정기간행물)] - Law CH / 2003 / Impact of lymph node retrieval and pathological ultra-staging on the prognosis of stage II colon cancer / J Surg Oncol 84 : 120 ~ 126
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UCI(KEPA) : I410-ECN-0101-2013-514-002650542