간세포암에서 Vimentin과 MMP2 발현의 임상적 의의

이은신; 홍성우; 강윤경; 이우용; 장여구; 백인욱; 이혁상

추천

검색

질문

자료유형: 학술저널

저자정보: 이은신 (인제대학교) 홍성우 (인제대학교) 강윤경 (인제대학교) 이우용 (인제대학교) 장여구 (인제대학교) 백인욱 (인제대학교) 이혁상 (인제대학교)

저널정보: 한국간담췌외과학회 Annals of Hepato-Biliary-Pancreatic Surgery 한국간담췌외과학회지 제13권 제2호

발행연도: 2009.6

수록면: 89 - 96 (8page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background / Purpose: Hepatocellular carcinoma (HCC) is a common cancer with a poor prognosis. A better understanding of the molecular mechanisms underlying the genesis of HCC, as well as the progression of HCC, allow for improved prediction of the prognosis of patients with HCC and more effective treatment. In this study, we determined the expression of vimentin and matrix metalloproteinase 2 (MMP 2) and evaluated the clinical significance in (HCC).
Methods: Immunohistochemical staining was performed for vimentin and MMP 2 in 98 surgically resected HCC specimens using the tissue microarray method. The clinicopathologic data and the outcomes were reviewed, and the levels of expression of vimentin and MMP 2 were compared.
Results: Positive expression of vimentin and MMP 2 was observed in 7.1% and 41.8% of specimens, respectively. The overexpression of vimentin and MMP 2 had a positive correlation with tumor cell proliferative activity, as measured by the Ki-67 labeling index (p<0.001 and p=0.043, respectively), but was not correlated with the TUNEL labeling index. Other clinicopathological factors, such as platelet count, serosal invasion, Edomondson grade, capsule infiltration, TNM stage(UICC, 6th edition) and extrahepatic metastases in patients with recurrences had a significant correlation with vimentin. The presence of portal vein thrombosis approached statistical significance with MMP 2 expression. In the survival analysis, overexpression of vimentin and MMP 2 was correlated with a poor overall survival rate based on univariate analysis (p=0.002 and, p=0.047, respectively), but not based on multivariate analysis.
Conclusion: In HCC, vimentin and MMP 2 may have a role in cancer progression with more aggressive potential, thus suggesting their use as a prognostic markers in HCC.

#Hepatocellular carcinoma #Vimentin, MMP 2 #Immunohistochemistry #Survival analysis #간세포암 #vimentin #MMP 2 #면역조직화학염색 #생존분석

참고문헌 (23)

참고문헌 신청

1. [학술지(정기간행물)] - Ben Ze’ev and Raz A / 1985 / Relationship between the organization and synthesis of vimentin and the metastatic capability of B16 melanoma cells / Cancer Res 45 : 2632 ~ 2641

2. [학술지(정기간행물)] - Domagala W / 1994 / P53 protein and vimentin in invasive ductal NOS breast carcinoma-relationship with survival and sites of metastases / Eur J Cancer 30 : 1527 ~ 1534

3. [학술지(정기간행물)] - Gilles C / 1996 / High level of MT-MMP expression is associated with invasiveness of cervical cancer cells / Int J Cancer 65 : 209 ~ 213

4. [학술지(정기간행물)] - Moch H / 1999 / Identification of prognostic parameters for renal cell carcinoma by cDNA arrays and cell chips / Verh Dtsch Ges Pathol 83 : 225 ~ 232

5. [학술지(정기간행물)] - Lang SH / 2002 / Enhanced expression of vimentin in motile prostate cell lines and in poorly differentiated and metastatic prostate carcinoma / Prostate 52 : 253 ~ 263

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!