The purpose of this study was to research to find out effects in hypertension relation gene expression in order for the accumulation of short duration exercise, ICR mice in three groups classification takes accumulation of short duration exercise group wheel running three times in the morning and fifteen minutes in the afternoon for 12 weeks. the duration exercise group also takes wheel running three times, 30 minutes in a 8 weeks after taking low-intensity exercise, the difference of a group in the muscle organization, and the difference of the hypertension relation gene UCP-2,3 m-RNA and ACE m-RNA expressions one-way ANOVA analysis inspect and in the accumulation of short duration exercise how much should have affected in the hypertension relation gene and with afterwards drew a same conclusion. In the UCP-2, 3m-RNA expression accumulation of short duration group was also significantly higher than the other group’s. but ACE m-RNA accumulation of short duration exercise group no significant difference between the group’s.