지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.88 No.2
- 발행연도
- 2015.1
- 수록면
- 77 - 85 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Astrocyte elevated gene-1 (AEG-1) plays important roles in tumorigenesis such as proliferation, invasion, metastasis, angiogenesis, and chemoresistance. We examined the expression of AEG-1 in patients with hepatocellular carcinoma (HCC).
Methods: Eighty-five samples were collected from patients with HCC who underwent surgery and were histopathologically confirmed to have HCC. Two independent pathologists, experienced in evaluating immunohistochemistry and blinded to the clinical outcomes of the patients, reviewed all samples. They determined AEG-1 expression semiquantitatively by assessing the percentage of positively stained immunoreactive cells and staining intensity. Clinicopathological data were analyzed in association with prognosis.
Results: The association was estimated by univariate and multivariate analyses with Cox regression. Tumor size (hazard ratio [HR], 2.285; 95% confidence interval [CI], 1.175?4.447; P = 0.015), microvascular invasion (HR, 6.754; 95% CI, 1.631?27.965; P = 0.008), and AEG-1 expression (HR, 4.756; 95% CI, 1.697?13.329; P = 0.003) were independent prognostic factors for overall survival. Those for disease-free survival rate were tumor size (HR, 2.245; 95% CI, 1.282?3.933; P = 0.005) and AEG-1 expression (HR, 1.916; 95% CI, 1.035?3.545; P = 0.038). The cumulative 5-year survival and recurrence rates were 89.2% and 50.0% in the low-expressing group and 24.5% and 82.4% in the high-expressing group, respectively.
Conclusion: The results suggest that AEG-1 overexpression could serve as a valuable prognostic marker in patients with HCC.
Methods: Eighty-five samples were collected from patients with HCC who underwent surgery and were histopathologically confirmed to have HCC. Two independent pathologists, experienced in evaluating immunohistochemistry and blinded to the clinical outcomes of the patients, reviewed all samples. They determined AEG-1 expression semiquantitatively by assessing the percentage of positively stained immunoreactive cells and staining intensity. Clinicopathological data were analyzed in association with prognosis.
Results: The association was estimated by univariate and multivariate analyses with Cox regression. Tumor size (hazard ratio [HR], 2.285; 95% confidence interval [CI], 1.175?4.447; P = 0.015), microvascular invasion (HR, 6.754; 95% CI, 1.631?27.965; P = 0.008), and AEG-1 expression (HR, 4.756; 95% CI, 1.697?13.329; P = 0.003) were independent prognostic factors for overall survival. Those for disease-free survival rate were tumor size (HR, 2.245; 95% CI, 1.282?3.933; P = 0.005) and AEG-1 expression (HR, 1.916; 95% CI, 1.035?3.545; P = 0.038). The cumulative 5-year survival and recurrence rates were 89.2% and 50.0% in the low-expressing group and 24.5% and 82.4% in the high-expressing group, respectively.
Conclusion: The results suggest that AEG-1 overexpression could serve as a valuable prognostic marker in patients with HCC.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Overexpression of Astrocyte Elevated Gene-1 (AEG-1) in Cervical Cancer and its Correlation with Angiogenesis
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
AEG-1 is Associated with Invasion and Poor Prognosis in Colorectal Cancer
대한임상종양학회 학술대회지
2015 .02
-
Clinical Comparison of Proximal Gastrectomy With Double-Tract Reconstruction Versus Total Gastrectomy With Roux-en-Y Anastomosis for Siewert Type II/III Adenocarcinoma of the Esophagogastric Junction
Journal of Gastric Cancer
2022 .07
-
Preoperative lymphocyte-to-C-reactive protein ratio predicts hepatocellular carcinoma recurrence after surgery
Annals of Surgical Treatment and Research
2022 .08
-
Prognostic Significance of Hes-1, a Downstream Target of Notch Signaling in Hepatocellular Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Partial Virological Response after 2 Years of Entecavir Therapy Increases the Risk of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Associated Cirrhosis
Gut and Liver
2021 .01
-
Association between hepatic steatosis and the development of hepatocellular carcinoma in patients with chronic hepatitis B
Clinical and Molecular Hepatology
2019 .01
-
Overexpression of PD-L1 and PD-L2 Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma
Cancer Research and Treatment
2017 .01
-
High Prevalence of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Infection in Thailand
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Prognostic value of preoperative protein-induced vitamin K absence or antagonist II after liver resection for hepatitis B-related hepatocellular carcinoma: a nationwide multicenter study
Annals of Surgical Treatment and Research
2022 .11
-
Independent Risk Factors for Hepatocellular Carcinoma Recurrence after Direct-Acting Antiviral Therapy in Patients with Chronic Hepatitis C
Gut and Liver
2021 .01
-
Seizing tumor factors for mortality and survival outcomes following liver resection in Indonesia’s hepatocellular carcinoma patients
Annals of Hepato-Biliary-Pancreatic Surgery
2025 .02
-
Tissue factor expression is associated with recurrence in patients with non-metastatic colorectal cancer
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2018 .12
-
Risk factors for poor survival after recurrence of hepatocellular carcinoma after liver transplantation
Annals of Surgical Treatment and Research
2021 .07
-
Survival-Related Factors of Spinal Metastasis with Hepatocellular Carcinoma in Current Surgical Treatment Modalities : A Single Institute Experience
대한신경외과학회지
2015 .01
-
Role of Surgery in Stage IV Hepatocellular Carcinoma (HCC)
대한임상종양학회 학술대회지
2015 .02
-
Obesity and hepatocellular carcinoma in patients receiving entecavir for chronic hepatitis B
Clinical and Molecular Hepatology
2016 .01
-
Clinicopathological Characteristics and Disease-Free Survival in Patients with Hurthle Cell Carcinoma: A Multicenter Cohort Study in South Korea
Endocrinology and Metabolism
2021 .10
-
Validation for models for tumor recurrence after liver transplantation in hepatectomy patients
Annals of Surgical Treatment and Research
2022 .03
-
Effects of hormone therapy on recurrence in endometrial cancer survivors: a nationwide study using the Korean Health Insurance Review and Assessment Service database
Journal of Gynecologic Oncology
2019 .01
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2016-514-001071630