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Effects of an aqueous extract of purple sweet potato on nonalcoholic fatty liver in high fat/cholesterol-fed mice
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고지방/고콜레스테롤 식이를 섭취한 마우스에서 자색고구마 열수추출물 보충이 지방간 저항성에 미치는 영향

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Type
Academic journal
Author
Lee, You Jin (이화여자대학교) Yang, Yoon Kyoung (숭의여자대학교) Kim, You Jin (이화여자대학교) Kwon, Oran (이화여자대학교)
Journal
The Korean Nutrition Society Journal of Nutrition and Health Vol.48 No.1 KCI Accredited Journals SCOPUS
Published
2015.2
Pages
1 - 8 (8page)

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Effects of an aqueous extract of purple sweet potato on nonalcoholic fatty liver in high fat/cholesterol-fed mice
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Purpose: Anthocyanins from purple sweet potato (PSP) have been investigated in vitro and in animals and found to have a protective effect against oxidative hepatic damage. In this study, we investigated that aqueous extract of PSP can ameliorate the dysfunction of lipid metabolism in mice fed a high fat/cholesterol diet. Methods: Forty C57BL/6J mice were randomly divided into 5 groups (n = 8) and fed one of the following diets for 8 weeks; normal fat (NF) diet; high fat/cholesterol (HFC) diet; HFC with 1.25% PSP (HFPL) diet; HFC with 2.5% PSP (HFPM) diet; HFC with 5% PSP (HFPH) diet. Results: Non-alcoholic fatty liver was manifested in the HFC group by showing increased levels in plasma alanine aminotransferase (ALT) activity, total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C), increased level of TC and presence of many large lipid droplets in the liver, and increased fat cell size in the HFC group compared with the NF group. However, administration of HFC induced a significant decrease in food intake, resulting in decrease in fat mass. Coadministration of PSP did not lead to reversal of body weight changes, ALT activity, and lipid levels in plasma and the liver, but suppressed excess enlargement of the fat cell size through increasing carnitine palmitoyltransferase-1 (CPT-1) gene expression in the liver. Accordingly, the number of fat droplets in the liver was reduced in PSP administered groups. Conclusion: Taken together, these results suggest that PSP may have a protective effect on the dysfunction of lipid metabolism. Conduct of further studies on the coordinated regulation of PSP for lipid metabolic homeostasis at the liveradipose tissue axis is needed.
#purple sweet potato #aqueous extract #high fat/cholesterol diet #non-alcoholic fatty liver

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1. [학술지(정기간행물)] - Samuel VT / 2004 / Mechanism of hepatic insulin resistance in nonalcoholic fatty liver disease / J Biol Chem 279 (31) : 32345 ~ 32353 google schola 2. [학술지(정기간행물)] - 이은 / 2003 / 지방간 환자를 위한 생식용 천연복합식품이 고지방식이를 급여한 흰쥐의 혈청, 간장의 효소 및 간조직 구조에 미치는 영향 / 한국식품영양과학회지 32 (2) : 256 ~ 262 dbpia 3. [보고서] - Ministry of Food and Drug Safety / 2012 / Influence of dietary intake on non-alcoholic fatty liver disease in Korean google schola 4. [학술지(정기간행물)] - 한규홍 / 2002 / 자색고구마를 이용한 민속주의 제조 및 생리 기능성 / 한국식품과학회지 34 (4) : 673 ~ 677 dbpia 5. [학술지(정기간행물)] - Rossi A / 2003 / Protective effects of anthocyanins from blackberry in a rat model of acute lung inflammation / Free Radic Res 37 (8) : 891 ~ 900 google schola

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