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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 126 - 130 (5page)
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초록· 키워드
오류제보하기
There are several studies that show hypothermia improves cellular ischemia damages on experimental and clinical bases. However, its exact molecular mechanisms are unclear. In this study, we demonstrate that hypothermia induced insulin-like growth factor 1 (IGF1) gene expression, and its expression was dramatically decreased under ischemic insults. It was also demonstrated that hypothermia activated endoplasmic reticulum (ER) stress sensors especially both the phosphorylation of eIF2α (eukaryotic translation initiation factor 2 alpha) and ATF6 (activating transcription factor-6) proteolytic cleavage. However, the factors of apoptosis and autophagy were not associated with hypothermia. We suggest that hypothermia-treated IGF1 gene expression after ischemia may show a good possibility for the development of treatments and diagnostic methods in cerebral ischemic damages.
목차
REFERENCES
참고문헌 (17)
참고문헌 신청
[학술지(정기간행물)] - Agrogiannis G / 2014 / Insulinlike growth factors in embryonic and fetal growth and skeletal development / Mol Med Rep 10 : 579 ~ 584
[학술지(정기간행물)] - Al-Fageeh MB / 2009 / Cold-inducible RNA binding protein(CIRP) expression is modulated by alternative mRNAs / RNA 15 : 1164 ~ 1176
[학술지(정기간행물)] - Bernard SA / 2002 / Treatment of comatous survivors of out-of-hospital cardiac arrest with induced hypothermia / N Engl J Med 346 : 557 ~ 563
[학술지(정기간행물)] - Braakman I / 2011 / Protein folding and modification in the mammalian endoplasmic reticulum / Annu Rev Biochem 80 : 71 ~ 99
[학술지(정기간행물)] - Holzer M / 2002 / Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest / N Engl J Med 346 : 549 ~ 556
[학술지(정기간행물)] - Al-Fageeh MB / 2009 / Cold-inducible RNA binding protein(CIRP) expression is modulated by alternative mRNAs / RNA 15 : 1164 ~ 1176
[학술지(정기간행물)] - Bernard SA / 2002 / Treatment of comatous survivors of out-of-hospital cardiac arrest with induced hypothermia / N Engl J Med 346 : 557 ~ 563
[학술지(정기간행물)] - Braakman I / 2011 / Protein folding and modification in the mammalian endoplasmic reticulum / Annu Rev Biochem 80 : 71 ~ 99
[학술지(정기간행물)] - Holzer M / 2002 / Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest / N Engl J Med 346 : 549 ~ 556
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UCI(KEPA) : I410-ECN-0101-2016-510-001658788