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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 230 - 238 (9page)
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초록· 키워드
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The MK1 strain, a novel bacterial isolate from soft-rotten tissue of the Neungee mushroom, produces copious amounts of exopolysaccharide (EPS) in a dextrose minimal medium. This study examined the molecular characteristics and immunomodulatory activity of MK1 EPS. Methods: The EPS in the culture supernatant was purified by cold ethanol precipitation, and characterized by SDS- PAGE/silver staining and Bio-HPLC. The immunomodulatory activities of the EPS were examined using the mouse monocytic cell line, RAW 264.7 cells. Results: The molecular weights of the purified EPS were rather heterogeneous, ranging from 10.6 to 55 kDa. The EPS was composed of glucose, rhamnose, mannose, galactose, and glucosamine at an approximate molar ratio of 1.00 : 0.8 : 0.71 : 0.29 : 0.21. EPS activated the RAW cells to produce cytokines, such as TNF-α and IL-1β, and nitric oxide (NO). EPS also induced the expression of co-stimulatory molecules, such as B7-1, B7-2 and ICAM-1, and increased the phagocytic activity. The macrophage-activating activity of EPS was not due to endotoxin contamination because the treatment of EPS with polymyin B did not reduce the macrophage-activating activity. Conclusion: The EPS produced from the MK1 strain exerts macrophage-activating activity.
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참고문헌 (48)
참고문헌 신청
1. [학술지(정기간행물)] - Welman AD / 2003 / Exopolysaccharides from lactic acid bacteria: perspectives and challenges / Trends Biotechnol 21 : 269 ~ 274
2. [학술지(정기간행물)] - Sutherland IW / 1972 / Bacterial exopolysaccharides / Adv Microb Physiol 8 : 143 ~ 213
3. [학술지(정기간행물)] - Wang H / 2007 / Structure and protective effect of exopolysaccharide from P. Agglomerans strain KFS-9 against UV radiation / Microbiol Res 162 : 124 ~ 129
4. [학술지(정기간행물)] - Sutherland I / 2001 / Biofilm exopolysaccharides: a strong and sticky framework / Microbiology 147 : 3 ~ 9
5. [학술지(정기간행물)] - Kumar CG / 2004 / Purification and characterization of an extracellular polysaccharide from haloalkalophilic Bacillus sp. I-450 / Enz Microbial Techno 34 : 673 ~ 681
2. [학술지(정기간행물)] - Sutherland IW / 1972 / Bacterial exopolysaccharides / Adv Microb Physiol 8 : 143 ~ 213
3. [학술지(정기간행물)] - Wang H / 2007 / Structure and protective effect of exopolysaccharide from P. Agglomerans strain KFS-9 against UV radiation / Microbiol Res 162 : 124 ~ 129
4. [학술지(정기간행물)] - Sutherland I / 2001 / Biofilm exopolysaccharides: a strong and sticky framework / Microbiology 147 : 3 ~ 9
5. [학술지(정기간행물)] - Kumar CG / 2004 / Purification and characterization of an extracellular polysaccharide from haloalkalophilic Bacillus sp. I-450 / Enz Microbial Techno 34 : 673 ~ 681
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