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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 553 - 559 (7page)
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초록· 키워드
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Prostaglandin (PG) E2 exerts its actions by acting on a group of G-protein-coupled receptors
(GPCRs). GPCRs responding to PGE2 consist of four subtypes namely E-prostanoid 1 (EP1),
E-prostanoid 2 (EP2), E-prostanoid 3 (EP3), and E-prostanoid 4 (EP4) and multiple splicing
isoforms of the subtype EP3. The EP subtypes exhibit differences in signal transduction pathway,
tissue localization, and regulation of expression. This molecular and biochemical heterogeneity
of PGE2 receptors leads to PGE2 being the most variable prostanoid. Studies on knockout
mice deficient in each EP subtype and selective agonist and antagonist have defined PGE2
actions mediated by each subtype and identified the role each EP subtype plays in various
physiological and pathophysiological responses. We summarize and review PGE2 receptor
research.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Abramovitz M / 2000 / The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs / Biochim Bioph
Bhattacharya M / 1999 / Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope / J Biol Chem 274 (22) : 15719 ~ 15724
Breyer RM / 2001 / Prostanoid receptors: subtypes and signaling / Annu Rev Pharmacol Toxicol (41) : 661 ~ 690
Cadigan KM / 1997 / Wnt signaling: a common theme in animal development / Genes Dev 11 (24) : 3286 ~ 3305
Castellone MD / 2005 / Prostaglandin E2 promotes colon cancer cell growth through a Gsaxin-beta-catenin signaling axis / Science 310 (5753) : 1504 ~ 1510
Bhattacharya M / 1999 / Localization of functional prostaglandin E2 receptors EP3 and EP4 in the nuclear envelope / J Biol Chem 274 (22) : 15719 ~ 15724
Breyer RM / 2001 / Prostanoid receptors: subtypes and signaling / Annu Rev Pharmacol Toxicol (41) : 661 ~ 690
Cadigan KM / 1997 / Wnt signaling: a common theme in animal development / Genes Dev 11 (24) : 3286 ~ 3305
Castellone MD / 2005 / Prostaglandin E2 promotes colon cancer cell growth through a Gsaxin-beta-catenin signaling axis / Science 310 (5753) : 1504 ~ 1510
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