지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.6
- 수록면
- 217 - 227 (11page)
이용수
초록· 키워드
오류제보하기
Trichomonas vaginalis causes inflammation of the prostate and has been detected in tissues of prostate cancers (PCa), prostatitis and benign prostatic hyperplasia. Obesity is a risk factor for PCa and causes a chronic subclinical inflammation. This chronic inflammation further exacerbates adipose tissue inflammation as results of migration and activation of macrophages. Macrophages are the most abundant immune cells in the PCa microenvironment. M2 macrophages, known as Tumor-Associated Macrophages, are involved in increasing cancer malignancy. In this study, conditioned medium (TCM) of PCa cells infected with live trichomonads contained chemokines that stimulated migration of the mouse preadipocytes (3T3-L1 cells). Conditioned medium of adipocytes incubated with TCM (ATCM) contained Th2 cytokines (IL-4, IL-13). Macrophage migration was stimulated by ATCM. In macrophages treated with ATCM, expression of M2 markers increased, while M1 markers decreased. Therefore, it is suggested that ATCM induces polarization of M0 to M2 macrophages. In addition, conditioned medium from the macrophages incubated with ATCM stimulates the proliferation and invasiveness of PCa. Our findings suggest that interaction between inflamed PCa treated with T. vaginalis and adipocytes causes M2 macrophage polarization, so contributing to the progression of PCa.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (45)
참고문헌 신청
Newman L / 2015 / Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting / PLoS One 10:e0143304
Gardner WA Jr / 1986 / Trichomonas vaginalis in the prostate gland / Arch Pathol Lab Med 110:430~432
Mitteregger D / 2012 / High detection rate of Trichomonas vaginalis in benign hyperplastic prostatic tissue / Med Microbiol Immunol 201:113~116
Seo MY / 2014 / Inflammatory response of prostate epithelial cells to stimulation by Trichomonas vaginalis / Prostate 74:441~449
Im SJ / 2016 / Inflammatory response of a prostate stromal cell line induced by Trichomonas vaginalis / Parasite Immunol 38:218~227
Gardner WA Jr / 1986 / Trichomonas vaginalis in the prostate gland / Arch Pathol Lab Med 110:430~432
Mitteregger D / 2012 / High detection rate of Trichomonas vaginalis in benign hyperplastic prostatic tissue / Med Microbiol Immunol 201:113~116
Seo MY / 2014 / Inflammatory response of prostate epithelial cells to stimulation by Trichomonas vaginalis / Prostate 74:441~449
Im SJ / 2016 / Inflammatory response of a prostate stromal cell line induced by Trichomonas vaginalis / Parasite Immunol 38:218~227
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UCI(KEPA) : I410-ECN-0101-2020-513-000883910