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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.8
- 수록면
- 431 - 438 (8page)
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초록· 키워드
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In Trichinella spiralis infection, type 2 helper T (Th2) cell-related and regulatory T (Treg) cell-related immune responses are the most important immune events. In order to clarify which Toll-like receptors (TLRs) are closely associated with these responses, we analyzed the expression of mouse TLR genes in the small intestine and muscle tissue during T. spiralis infection. In addition, the expression of several chemokine- and cytokine-encoding genes, which are related to Th2 and Treg cell mediated immune responses, were analyzed in mouse embryonic fibroblasts (MEFs) isolated from myeloid differentiation factor 88 (MyD88)/TIR-associated proteins (TIRAP) and Toll receptor-associated activator of interferons (TRIF) adapter protein deficient and wild type (WT) mice. The results showed significantly increased TLR4 and TLR9 gene expression in the small intestine after 2 weeks of T. spiralis infection. In the muscle, TLR1, TLR2, TLR5, and TLR9 gene expression significantly increased after 4 weeks of infection. Only the expression of the TLR4 and TLR9 genes was significantly elevated in WT MEF cells after treatment with excretory-secretory (ES) proteins. Gene expression for Th2 chemokine genes were highly enhanced by ES proteins in WT MEF cells, while this elevation was slightly reduced in MyD88/TIRAP-/- MEF cells, and quite substantially decreased in TRIF-/- MEF cells. In contrast, IL-10 and TGF-β expression levels were not elevated in MyD88/TIRAP-/- MEF cells. In conclusion, we suggest that TLR4 and TLR9 might be closely linked to Th2 cell and Treg cell mediated immune responses, although additional data are needed to convincingly prove this observation.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (20)
참고문헌 신청
[학술지(정기간행물)] - Sawant DV / 2014 / Regulatory T cells limit induction of protective immunity and promote immune pathology following intestinal helminth infection / J Immunol 192 : 2904 ~ 2912
[학술지(정기간행물)] - McSorley HJ / 2008 / Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi / J Immunol 181 : 6456 ~ 6466
[학술지(정기간행물)] - Kang SA / 2014 / Parasitic nematode-induced CD4+Foxp3+ T cells can ameliorate allergic airway inflammation / PLoS Negl Trop Dis 8 : e3410 ~
[학술지(정기간행물)] - Kang SA / 2012 / Alteration of helper T-cell related cytokine production in splenocytes during Trichinella spiralis infection / Vet Parasitol 186 : 319 ~ 327
[학술지(정기간행물)] - Beutler B / 2004 / Inferences, questions and possibilities in Toll-like receptor signalling / Nature 430 (6996) : 257 ~ 263
[학술지(정기간행물)] - McSorley HJ / 2008 / Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi / J Immunol 181 : 6456 ~ 6466
[학술지(정기간행물)] - Kang SA / 2014 / Parasitic nematode-induced CD4+Foxp3+ T cells can ameliorate allergic airway inflammation / PLoS Negl Trop Dis 8 : e3410 ~
[학술지(정기간행물)] - Kang SA / 2012 / Alteration of helper T-cell related cytokine production in splenocytes during Trichinella spiralis infection / Vet Parasitol 186 : 319 ~ 327
[학술지(정기간행물)] - Beutler B / 2004 / Inferences, questions and possibilities in Toll-like receptor signalling / Nature 430 (6996) : 257 ~ 263
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UCI(KEPA) : I410-ECN-0101-2016-513-001839479