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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 177 - 181 (5page)
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초록· 키워드
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Allergy is an immune response that appears in certain people, and reactions such as coughing, shortness of breath, and hives occur. The immune system plays an important role in homeostasis and host defense, and allergies cause hypersensitivity reactions when an imbalance of immunity occurs. Mutations in the TLR genes are associated with autoimmune conditions such as allergies and asthma. It has been reported that a locus in the TLR1-TLR6-TLR10 region may be associated with atopic sensitization or allergy. Therefore, the purpose of this study was to select an allergy patient group and a healthy control group to determine how the genetic mutation of TLR1 affects the onset of disease. This study was conducted in 709 patients and 5,025 control groups out of 10,956 patients with data from KARE and HEXA cohorts. As a result of logistic regression analysis of 6 SNPs selected from the TLR1 gene, only rs117033348 showed a statistically significant correlation (P = 0.002356). The influence of rs117033348 was examined using PolyPhen-2, and a significant result was shown. Therefore, it can be predicted that the G base in rs117033348 will have an influence on the human body. In addition, Geography of Genetic Variants browser was used to confirm the geographical distribution of allele frequencies for the TLR1 gene. Although it was found that there was a large racial difference in the prevalence of TLR1 SNP, it could be confirmed that the polymorphism of rs117033348 conducted in this study was only specific in East Asia when compared with each race.
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참고문헌 (27)
참고문헌 신청
Ben-Ali M / 2011 / Functional characterization of naturally occurring genetic variants in the human TLR1-2-6gene family / Hum Mutat 32:643~652
Bønnelykke K / 2015 / Genetics of allergy and allergic sensitization : common variants, rare mutations / Curr Opin Immunol 36:115~126
Charfi A / 2010 / Rhinites allergiques [Allergic rhinitis] / Tunis Med 88:690~695
Cho YS / 2009 / A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nat Genet 41:527~534
Choi HG / 2021 / Asthma, Allergic Rhinitis, and Atopic Dermatitis Incidence in Korean Adolescents before and after COVID-19 / J Clin Med 10:3446
Bønnelykke K / 2015 / Genetics of allergy and allergic sensitization : common variants, rare mutations / Curr Opin Immunol 36:115~126
Charfi A / 2010 / Rhinites allergiques [Allergic rhinitis] / Tunis Med 88:690~695
Cho YS / 2009 / A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nat Genet 41:527~534
Choi HG / 2021 / Asthma, Allergic Rhinitis, and Atopic Dermatitis Incidence in Korean Adolescents before and after COVID-19 / J Clin Med 10:3446
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