지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 216 - 226 (11page)
이용수
초록· 키워드
오류제보하기
Background/Aims: Toll-like receptors (TLRs) modulate T cell responses in diverse diseases. Co-stimulation of T cell activation via TLR9 induces production of interferon gamma (IFN-γ), priming of which is critical for differentiation of proinflammatory macrophages. These macrophages have a crucial role in nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the expression of TLR9 protein on T cells and the consequences of TLR9-mediated triggering of these cells in patients with NAFLD. Methods: Our study included 34 patients with simple steatosis, 34 patients with nonalcoholic steatohepatitis, eight patients with NAFLD who met general diagnostic criteria but lacked histological diagnosis, and 51 control subjects. We used a synthetic TLR9 ligand to co-stimulate T cells. We measured TLR9 expression in liver and peripheral T cells and CD69 and IFN-γ as phenotypic markers of T cell activation and differentiation by flow cytometry. Results: TLR9 expression on liver and peripheral T cells was lowest in patients with simple steatosis and was positively associated with anthropometric, biochemical, and histopathological features of NAFLD. In vitro co-stimulation of T cells from patients with simple steatosis induced a limited number of IFN-γ-producing CD8+ T cells. At baseline, these patients showed a low frequency of circulating type 1 CD8+ cells. Conclusions: The positive associations between TLR9 and anthropometric, clinical, and histological features and the crucial role of IFN-γ-in NAFLD suggest that limited TLR9 expression and production of IFN-γ play a protective role in patients with simple steatosi
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Day CP / 2006 / From fat to inflammation / Gastroenterology 130:207~210
Wan J / 2014 / M2 Kupffer cells promote M1 Kupffer cell apoptosis : a protective mechanism against alcoholic and nonalcoholic fatty liver disease / Hepatology 59:130~142
Armant MA / 2002 / Toll-like receptors : a family of pattern-recognition receptors in mammals / Genome Biol 3:3011.1~3011.6
Miura K / 2010 / Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1β in mice / Gastroenterology 139:323~334.e7
Rose II WA / 2012 / TLR9 is important for protection against intestinal damage and for intestinal repair / Sci Rep 2:574
Wan J / 2014 / M2 Kupffer cells promote M1 Kupffer cell apoptosis : a protective mechanism against alcoholic and nonalcoholic fatty liver disease / Hepatology 59:130~142
Armant MA / 2002 / Toll-like receptors : a family of pattern-recognition receptors in mammals / Genome Biol 3:3011.1~3011.6
Miura K / 2010 / Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1β in mice / Gastroenterology 139:323~334.e7
Rose II WA / 2012 / TLR9 is important for protection against intestinal damage and for intestinal repair / Sci Rep 2:574
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
TLR10 and Its Unique Anti-Inflammatory Properties and Potential Use as a Target in Therapeutics
Immune Network
2020 .06
-
The Roles of the Gut Microbiota and Toll-like Receptors in Obesity and Nonalcoholic Fatty Liver Disease
Journal of Obesity & Metabolic Syndrome
2017 .01
-
Toll-like Receptor 2 in Autoimmune Inflammation
Immune Network
2021 .06
-
Variable localization of Toll-like receptors in human fallopian tube epithelial cells
Clinical and experimental reproductive medicine : CERM
2018 .01
-
Two Sjogren syndrome-associated oral bacteria, Prevotella melaninogenica and Rothia mucilaginosa, induce the upregulation of major histocompatibility complex class I and hypoxia-associated cell death, respectively, in human salivary gland cells
International Journal of Oral Biology
2021 .12
-
Toll-Like Receptor Gene Expression during Trichinella spiralis Infection
Parasites, Hosts and Diseases
2015 .08
-
Association with Genetic Polymorphism of rs117033348 and Allergic Disease in Korean Population
대한의생명과학회지
2021 .09
-
Clinical Significance of Toll-Like Receptor and Toll-Like Receptor Blocker
Urogenital Tract Infection
2016 .01
-
Sex hormones alter the response of Toll-like receptor 3 to its specific ligand in fallopian tube epithelial cells
Clinical and experimental reproductive medicine : CERM
2018 .01
-
Association of Single Nucleotide Polymorphisms in Toll-like Receptor Genes With Asthma Risk: A Systematic Review and Meta-analysis
Allergy, Asthma & Immunology Research
2015 .01
-
Pristimerin Inhibits Inducible Nitric Oxide Synthase Expression Induced by TLR Agonists
대한의생명과학회지
2019 .03
-
Inhibition of TLR signaling by cell-penetrating peptide ameliorates DSS-induced colitis through the modulation of type 17 helper T cells
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Dehydrocostus Lactone Suppresses the Expression of iNOS Induced by TLR Agonists
대한의생명과학회지
2019 .09
-
Cell penetrating TLR antagonist peptide inhibits the TLR-MyD88 signaling and mitigates MRSA-induced sepsis
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Estudy the Effect of Breast Cancer on Tlr2 Expression in Nb4 Cell
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Limited expression of toll-like receptor 9 on T cells and its functional consequences in patients with nonalcoholic fatty liver disease
Clinical and Molecular Hepatology
2020 .01
-
Decreased expression of Toll-like receptor 4 and 5 during progression of prostate transformation in transgenic adenocarcinoma of mouse prostate mice
Journal of Veterinary Science
2015 .09
-
Cathepsin S exacerbates lupus pathogenesis in transgenic mice by regulating TLR7 and IFN-α
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Pathophysiological Role of TLR4 in Chronic Relapsing Itch Induced by Subcutaneous Capsaicin Injection in Neonatal Rats
Immune Network
2022 .04
-
Toll-like receptor 2 promotes neurogenesis from the dentate gyrus after photothrombotic cerebral ischemia in mice
The Korean Journal of Physiology & Pharmacology
2018 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0