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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 190 - 199 (10page)
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초록· 키워드
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Despite evidence that bacteria-sensing Toll-like receptors (TLRs) are activated in salivary gland tissues of Sjogren syndrome (SS) patients, the role of oral bacteria in SS etiopathogenesis is unclear. We previously reported that two SS-associated oral bacteria, Prevotella melaninogenica (Pm) and Rothia mucilagenosa (Rm), oppositely regulate the expression of major histocompatibility complex class I (MHC I) in human salivary gland (HSG) cells. Here, we elucidated the mechanisms underlying the differential regulation of MHC I expression by these bacteria. The ability of Pm and Rm to activate TLR2, TLR4, and TLR9 was examined using TLR reporter cells. HSG cells were stimulated by the TLR ligands, Pm, and Rm. The levels of MHC I expression, bacterial invasion, and viability of HSG cells were examined by flow cytometry. The hypoxic status of HSG cells was examined using Hypoxia Green. HSG cells upregulated MHC I expression in response to TLR2, TLR4, and TLR9 activation. Both Pm and Rm activated TLR2 and TLR9 but not TLR4. Rm-induced downregulation of MHC I strongly correlated with bacterial invasion and cell death. Rm-induced cell death was not rescued by inhibitors of the diverse cell death pathways but was associated with hypoxia. In conclusion, Pm upregulated MHC I likely through TLR2 and TLR9 activation, while Rm-induced hypoxia-associated cell death and the downregulation of MHC I, despite its ability to activate TLR2 and TLR9. These findings may provide new insight into how oral dysbiosis can contribute to salivary gland tissue damage in SS.
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참고문헌 (27)
참고문헌 신청
Maślińska M / 2015 / Sjögren’s syndrome : still not fully understood disease / Rheumatol Int 35:233~241
Shiboski SC / 2012 / American College of Rheumatology classification criteria for Sjögren’s syndrome: a data-driven, expert consensus approach in the Sjögren’s International Collaborative Clinical Alliance cohort / Arthritis Care Res(Hoboken) 64:475~487
Christodoulou MI / 2010 / Characteristics of the minor salivary gland infiltrates in Sjögren’s syndrome / J Autoimmun 34:400~407
Mitsias DI / 2006 / Sjögren’s syndrome : why autoimmune epithelitis / Oral Dis 12:523~532
Tsunawaki S / 2002 / Possible function of salivary gland epithelial cells as nonprofessional antigen-presenting cells in the development of Sjögren’s syndrome / J Rheumatol 29:1884~1896
Shiboski SC / 2012 / American College of Rheumatology classification criteria for Sjögren’s syndrome: a data-driven, expert consensus approach in the Sjögren’s International Collaborative Clinical Alliance cohort / Arthritis Care Res(Hoboken) 64:475~487
Christodoulou MI / 2010 / Characteristics of the minor salivary gland infiltrates in Sjögren’s syndrome / J Autoimmun 34:400~407
Mitsias DI / 2006 / Sjögren’s syndrome : why autoimmune epithelitis / Oral Dis 12:523~532
Tsunawaki S / 2002 / Possible function of salivary gland epithelial cells as nonprofessional antigen-presenting cells in the development of Sjögren’s syndrome / J Rheumatol 29:1884~1896
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