지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.9
- 수록면
- 164 - 169 (6page)
이용수
초록· 키워드
오류제보하기
Atherosclerosis is a cardiovascular disease in which plaque builds up inside of an artery and can lead to various complications such as myocardial infarction, stroke, and thrombosis. Recently, hypertriglyceridemia has attracted significant attention as contributors to development of atherosclerosis. However, molecular mechanism of its contribution to atherosclerosis is poorly understood. Here we proposed a potential link between triglyceride (TG) and atherosclerosis. TG treatment promoted downregulation of certain scavenger receptor, macrophage scavenger receptor-1 (MSR-1) in phorbol myristate acetate (PMA)-derived human macrophages. TG treatment caused reduction of MSR-1 mRNA expression in a time- and dose-dependent manner. Using chemical inhibitors, we found that inhibition of signaling pathways associated with PI3K and PLC enhances TG-induced reduction of MSR-1 expression in THP-1 macrophages implying that PI3K and PLC is implicated in the expression of MSR-1 in macrophages. Since MSR-1 is associated with uptake and clearance of atherogenic lipoprotein, oxidized low density lipoprotein (oxi-LDL), our data suggest that increase of oxi-LDL due to TG-mediated reduction of its receptor MSR-1 can promote atherosclerosis.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (17)
참고문헌 신청
Aronis A / 2005 / Mechanism underlying oxidative stress-mediated lipotoxicity: Exposure of j774.2 macrophages to triacylglycerols facilitates mitochondrial reactive oxygen species production and cellular necrosis / Free Radic Biol Med 38:1221~1230
Carmena R / 2004 / Atherogenic lipoprotein particles in atherosclerosis / Circulation 109:III2~III7
Chin JH / 1992 / Inactivation of endothelial derived relaxing factor by oxidized lipoproteins / J Clin Invest 89:10~18
de Winther MP / 1999 / Scavenger receptor deficiency leads to more complex atherosclerotic lesions in apoe3leiden transgenic mice / Atherosclerosis 144:315~321
Griffin EE / 2005 / Aggregated ldl and lipid dispersions induce lysosomal cholesteryl ester accumulation in macrophage foam cells / J Lipid Res 46:2052~2060
Carmena R / 2004 / Atherogenic lipoprotein particles in atherosclerosis / Circulation 109:III2~III7
Chin JH / 1992 / Inactivation of endothelial derived relaxing factor by oxidized lipoproteins / J Clin Invest 89:10~18
de Winther MP / 1999 / Scavenger receptor deficiency leads to more complex atherosclerotic lesions in apoe3leiden transgenic mice / Atherosclerosis 144:315~321
Griffin EE / 2005 / Aggregated ldl and lipid dispersions induce lysosomal cholesteryl ester accumulation in macrophage foam cells / J Lipid Res 46:2052~2060
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UCI(KEPA) : I410-ECN-0101-2020-510-001306046