Significance of micrometastases in the calculation of the lymph node ratio for papillary thyroid cancer

Young Woo Chang; Hwan Soo Kim; Seung Pil Jung; Hoon Yub Kim; Jae Bok Lee; Jeoung Won Bae; Gil Soo Son

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자료유형: 학술저널

저자정보: Young Woo Chang (Korea University College of Medicine) Hwan Soo Kim (Korea University College of Medicine) Seung Pil Jung (Korea University College of Medicine) Hoon Yub Kim (Korea University College of Medicine) Jae Bok Lee (Korea University College of Medicine) Jeoung Won Bae (Korea University College of Medicine) Gil Soo Son (Korea University College of Medicine)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.92 No.3

발행연도: 2017.3

수록면: 117 - 122 (6page)

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Purpose: The lymph node ratio (LNR) is an important prognostic factor in papillary thyroid carcinoma (PTC), but micrometastases in cervical lymph nodes (LNs) are not of great clinical importance. In this study, we analyzed the accuracy of prediction of the prognosis depending on whether micrometastases were included in the number of metastatic LNs when calculating LNR.
Methods: The study included 353 PTC patients who underwent total thyroidectomy with neck LN dissection, and calculated LNR by 2 methods according to whether micrometastases were included in the number of metastatic LNs: Method 1 did not and method 2 did include. To compare the predictive values of LNR by the 2 methods, correlation coefficients and receiver operating characteristic (ROC) curves were analyzed.
Results: Positive correlations were found between LNR and preablation stimulated thyroglobulin (sTg) levels in both methods, but the correlation between method 1 LNR and preablation sTg level was significantly stronger than that for method 2 (Fisher z = 1.7, P = 0.045). The areas under these 2 independent ROC curves were analyzed; the prognostic efficacy of method 1 LNR was more accurate than that of method 2 LNR, and the difference was statistically significant (P = 0.0001).
Conclusion: Regional recurrence of PTC can be predicted more accurately by not including micrometastases in the number of metastatic LNs when calculating LNR.

#Papillary thyroid carcinoma #Lymph nodes

참고문헌 (26)

참고문헌 신청

[학술지(정기간행물)] - DeGroot LJ / 1990 / Natural history, treatment, and course of papillary thyroid carcinoma / J Clin Endocrinol Metab 71 : 414 ~ 424

[학술지(정기간행물)] - Tubiana M / 1985 / Long-term results and prognostic factors in patients with differentiated thyroid carcinoma / Cancer 55 : 794 ~ 804

[학술지(정기간행물)] - Samaan NA / 1983 / Impact of therapy for differentiated carcinoma of the thyroid : an analysis of 706 cases / J Clin Endocrinol Metab 56 : 1131 ~ 1138

[학술지(정기간행물)] - Sivanandan R / 2001 / Pattern of cervical lymph node metastases from papillary carcinoma of the thyroid / Br J Surg 88 : 1241 ~ 1244

[학술지(정기간행물)] - Grant CS / 1988 / Local recurrence in papillary thyroid carcinoma: is extent of surgical resection important? / Surgery 104 : 954 ~ 962

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