지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 36 - 42 (7page)
이용수
초록· 키워드
오류제보하기
Background: Some differences have been reported in the biotransformation of ginsenosides, probably due to the types of materials used such as ginseng, enzymes, and microorganisms. Moreover, most microorganisms used for transforming ginsenosides do not meet food-grade standards. We investigated the statistical conversion rate of major ginsenosides in ginsenosides model culture during fermentation by lactic acid bacteria (LAB) to estimate possible pathways.
Methods: Ginsenosides standard mix was used as a model culture to facilitate clear identification of the metabolic changes. Changes in eight ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, and Rg2) during fermentation with six strains of LAB were investigated.
Results: In most cases, the residual ginsenoside level decreased by 5.9e36.8% compared with the initial ginsenoside level. Ginsenosides Rb1, Rb2, Rc, and Re continuously decreased during fermentation. By contrast, Rd was maintained or slightly increased after 1 d of fermentation. Rg1 and Rg2 reached their lowest values after 1e2 d of fermentation, and then began to increase gradually. The conversion of Rd, Rg1, and Rg2 into smaller deglycosylated forms was more rapid than that of Rd from Rb1, Rb2, and Rc, as well as that of Rg1 and Rg2 from Re during the first 2 d of fermentation with LAB.
Conclusion: Ginsenosides Rb1, Rb2, Rc, and Re continuously decreased, whereas ginsenosides Rd, Rg1, and Rg2 increased after 1e2 d of fermentation. This study may provide new insights into the metabolism of ginsenosides and can clarify the metabolic changes in ginsenosides biotransformed by LAB.
Methods: Ginsenosides standard mix was used as a model culture to facilitate clear identification of the metabolic changes. Changes in eight ginsenosides (Rb1, Rb2, Rc, Rd, Re, Rf, Rg1, and Rg2) during fermentation with six strains of LAB were investigated.
Results: In most cases, the residual ginsenoside level decreased by 5.9e36.8% compared with the initial ginsenoside level. Ginsenosides Rb1, Rb2, Rc, and Re continuously decreased during fermentation. By contrast, Rd was maintained or slightly increased after 1 d of fermentation. Rg1 and Rg2 reached their lowest values after 1e2 d of fermentation, and then began to increase gradually. The conversion of Rd, Rg1, and Rg2 into smaller deglycosylated forms was more rapid than that of Rd from Rb1, Rb2, and Rc, as well as that of Rg1 and Rg2 from Re during the first 2 d of fermentation with LAB.
Conclusion: Ginsenosides Rb1, Rb2, Rc, and Re continuously decreased, whereas ginsenosides Rd, Rg1, and Rg2 increased after 1e2 d of fermentation. This study may provide new insights into the metabolism of ginsenosides and can clarify the metabolic changes in ginsenosides biotransformed by LAB.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Ye L / 2010 / Biotransformation of ginsenoside Rb1 to ginsenoside Rd by highly substratetolerant Paecilomyces Bainier 229-7 / Bioresour Technol 101 : 7872 ~ 7876
[학술지(정기간행물)] - Baque MA / 2012 / Production of biomass and useful compounds from adventitious roots of high-value added medicinal plants using bioreactor / Biotechnol Adv 30 : 1255 ~ 1267
[학술지(정기간행물)] - Jia L / 2009 / Current evaluation of the millennium phytomedicinedginseng (II): collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine / Curr Med Chem 16 : 2924 ~ 2942
[학술지(정기간행물)] - Li W / 2000 / Use of high-performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C. A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng) / J Anal Chem 72 : 5417 ~ 5422
[학술지(정기간행물)] - Su JH / 2006 / Enzymatic transformation of ginsenoside Rg3 to Rh2 using newly isolated Fusarium proliferatum ECU2042 / J Mol Catal B Enzym 38 : 113 ~ 118
[학술지(정기간행물)] - Baque MA / 2012 / Production of biomass and useful compounds from adventitious roots of high-value added medicinal plants using bioreactor / Biotechnol Adv 30 : 1255 ~ 1267
[학술지(정기간행물)] - Jia L / 2009 / Current evaluation of the millennium phytomedicinedginseng (II): collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine / Curr Med Chem 16 : 2924 ~ 2942
[학술지(정기간행물)] - Li W / 2000 / Use of high-performance liquid chromatography-tandem mass spectrometry to distinguish Panax ginseng C. A. Meyer (Asian ginseng) and Panax quinquefolius L. (North American ginseng) / J Anal Chem 72 : 5417 ~ 5422
[학술지(정기간행물)] - Su JH / 2006 / Enzymatic transformation of ginsenoside Rg3 to Rh2 using newly isolated Fusarium proliferatum ECU2042 / J Mol Catal B Enzym 38 : 113 ~ 118
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Kinetic study for the optimization of ginsenoside Rg3 production by heat treatment of ginsenoside Rb1
Journal of Ginseng Research
2015 .10
-
Variations in Ginsenosides of Raw Ginseng According to Heating Temperature and Time
Journal of Pharmacopuncture
2020 .01
-
인삼의 열처리 과정 중 생성되는 3종의 수산화진세노사이드에 대한 연구
생약학회지(Korean Journal of Pharmacognosy)
2020 .12
-
Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions
Journal of Ginseng Research
2018 .04
-
Effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng
Journal of Ginseng Research
2018 .01
-
Modification of ginsenoside composition in red ginseng (Panax ginseng) by ultrasonication
Journal of Ginseng Research
2016 .07
-
Roles of ginsenosides in sepsis
Journal of Ginseng Research
2023 .01
-
Influence of organic acids and heat treatment on ginsenoside conversion
Journal of Ginseng Research
2018 .10
-
Microbial conversion of major ginsenosides in ginseng total saponins by Platycodon grandiflorum endophytes
Journal of Ginseng Research
2016 .10
-
Effects of gut microbiota on the pharmacokinetics of protopanaxadiol ginsenosides Rd, Rg3, F2, and compound K in healthy volunteers treated orally with red ginseng
Journal of Ginseng Research
2020 .07
-
Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases
Journal of Ginseng Research
2017 .10
-
Accumulation characteristics and correlation analysis of five ginsenosides with different cultivation ages from different regions
Journal of Ginseng Research
2015 .10
-
An optimized microwave-assisted extraction method for increasing yields of rare ginsenosides from Panax quinquefolius L.
Journal of Ginseng Research
2016 .10
-
Changes in the ginsenoside content during the fermentation process using microbial strains
Journal of Ginseng Research
2015 .10
-
Enzymatic formation of compound-K from ginsenoside Rb1 by enzyme preparation from cultured mycelia of Armillaria mellea
Journal of Ginseng Research
2016 .04
-
20년 이상 장기저장된 홍삼의 이화학적 특성변화 및 품질안정성
생약학회지(Korean Journal of Pharmacognosy)
2017 .12
-
Protective effect of ginsenoside Rb1 against tacrolimus-induced apoptosis in renal proximal tubular LLC-PK1 cells
Journal of Ginseng Research
2018 .01
-
Ginsenoside Rb1함유 필름의 구강 내 창상 회복 촉진 효과
대한소아치과학회지
2022 .08
-
Improved antimicrobial effect of ginseng extract by heat transformation
Journal of Ginseng Research
2017 .04
-
Inhibitory Effect of Ginsenosides Rh1 and Rg2 on Oxidative Stress in LPS-Stimulated RAW 264.7 Cells
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2018 .12
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-524-001598663