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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 35 - 40 (6page)
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초록· 키워드
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Objectives : Zizyphus jujube (ZJ) has been used as a traditional medicine for various diseases. However, the inhibitory effect of ZJ on intestinal inflammation has not been fully understood, yet. The aim of this study is to investigate anti-colitis activity of ZJ in dextran sulfate sodium (DSS)-induced colitis mouse model. Methods : To investigate the protective effects of ZJ,the colitis mice were induced by drinking water containing 5% DSS for 7 days. Mice were randomized into groups receiving ZJ (500 mg/kg), sulfasalazine (SFZ) (150 mg/kg) as a positive control, or water as a negative control. We assayed the effects of ZJ on DSS-induced the clinical signs, measuring weight loss, colon length and disease activity index (DAI). Additionally, to find a possible explanation for the anti-inflammatory effects of ZJ, we evaluated the effects of ZJ on the production of prostaglandin $E_2$ ($PGE_2$) and expression of cyclooxygenase (COX)-2 in colitis tissue. Results : The results showed that mice treated with DSS showed considerable clinical signs, including weight loss, and reduced colon length. However, administration of ZJ significantly reduced the weight loss, shortens colon length, and improved DAI as clinical symptoms. Moreover, ZJ inhibited the $PGE_2$ production and COX-2 expression levels in DSS-treated colon tissues. Conclusions : Collectively, the findings of this study provide us with novel insights into the pharmacological actions of ZJ as a potential molecule for use in the treatment of intestinal inflammation including ulcerative colitis.
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참고문헌 (21)
참고문헌 신청
Han BH / 1993 / Sedative activity of aporphine and cyclopeptide alkaoids isolated from the seed of Zizyphus vulgaris var. Spinosus, and the fruits and stem bark of Zizyphus jujuba var. Inermis in mice / J Pharm Soc Korea 37(2):143~148
Heo HJ / 2003 / Effects of oleamide on choline acetyltransferase and cognitive activities / Biosci Biotechnol Biochem 67(6):1284~1291
Huang YL / 2008 / Effects of water-soluble carbohydrate concentrate from Chinese jujube on different intestinal and fecal indices / J Agric Food Chem 56(5):1734~1739
Naftali T / 2008 / Ziziphus jujuba extract for the treatment of chronic idiopathic constipation: a controlled clinical trial / Digestion 78(4):224~228
Hyams JS / 2000 / Inflammatory bowel disease / Pediatr Rev 21(9):291~295
Heo HJ / 2003 / Effects of oleamide on choline acetyltransferase and cognitive activities / Biosci Biotechnol Biochem 67(6):1284~1291
Huang YL / 2008 / Effects of water-soluble carbohydrate concentrate from Chinese jujube on different intestinal and fecal indices / J Agric Food Chem 56(5):1734~1739
Naftali T / 2008 / Ziziphus jujuba extract for the treatment of chronic idiopathic constipation: a controlled clinical trial / Digestion 78(4):224~228
Hyams JS / 2000 / Inflammatory bowel disease / Pediatr Rev 21(9):291~295
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