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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 283 - 289 (7page)
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초록· 키워드
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Naturally occurring antioxidants, such as polyphenols are widely found in fruits, vegetables, wines, juices, and other plant-based dietary sources and are divided into several sub classes, including phenylpropanoids, flavonoids, stilbenoids, and lignans. As part of the our ongoing search for bioactive food ingredients, the antioxidant and advanced glycation end products (AGEs) formation inhibitory activities of the methanolic extract of the aerial parts of Cirsium setidens were investigated in vitro bioassay system. The antioxidant properties were evaluated through radical scavenging assays using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS<SUP>+</SUP>) radicals. In addition, the activity of C. setidens against diabetes complications was also tested via AGEs formation inhibition assay. The total phenolic contents were determined using a UV-VIS spectrophotometric method. All tested samples showed a dose-dependent radical scavenging and AGEs inhibitory activities. In particular, the n-butanol (BuOH)-soluble portion showed the most potent radical scavenging activities against DPPH and ABTS<SUP>+</SUP>radicals with IC<SUB>50</SUB> values of 24.3±1.7 and 25.0±3.3 μg/mL, respectively. Futhermore, the inhibition of AGEs formation by the n-BuOH-soluble portion (IC<SUB>50</SUB> value; 46.0±1.5 μg/mL) was higher than that those of the soluble portions for the other solvent. The results showed that C. setidens could be considered as an effective source of natural antioxidants and other ingredients.
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참고문헌 (35)
참고문헌 신청
[학술지(정기간행물)] - Brownlee M / 2005 / The pathobiology of diabetic complications: A unifying mechanism / Diabetes 54 : 1615 ~ 1625
[학술지(정기간행물)] - Ahmed N / 2005 / Advanced glycation endproducts-role in pathology of diabetic complications / Diabetes Res Clin Pract 67 : 3 ~ 21
[학술지(정기간행물)] - Huebschmann AG / 2006 / Diabetes and advanced glycoxidation end products / Diabetes Care 29 : 1420 ~ 1432
[기타자료] - Huebschmann AG / 2007 / Diabetes and advanced glycoxidation end products / Annual Review of Diabetes : 51 ~ 63
[학술지(정기간행물)] - Matsuda H / 2003 / Structure requirements of flavonoids for inhibition of protein glycation and radical scavenging activities / Bioor Med Chem 11 : 5317 ~ 5323
[학술지(정기간행물)] - Ahmed N / 2005 / Advanced glycation endproducts-role in pathology of diabetic complications / Diabetes Res Clin Pract 67 : 3 ~ 21
[학술지(정기간행물)] - Huebschmann AG / 2006 / Diabetes and advanced glycoxidation end products / Diabetes Care 29 : 1420 ~ 1432
[기타자료] - Huebschmann AG / 2007 / Diabetes and advanced glycoxidation end products / Annual Review of Diabetes : 51 ~ 63
[학술지(정기간행물)] - Matsuda H / 2003 / Structure requirements of flavonoids for inhibition of protein glycation and radical scavenging activities / Bioor Med Chem 11 : 5317 ~ 5323
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