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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 361 - 369 (9page)
이용수
초록· 키워드
오류제보하기
Ginsenosides, dammarane-type triterpene saponins obtained from ginseng, have been used as a natural medicine for many years in the Orient due to their various pharmacological activities. However, the therapeutic potential of ginsenosides has been largely limited by the low bioavailability of the natural products caused mainly by low aqueous solubility, poor biomembrane permeability, instability in the gastrointestinal tract, and extensive metabolism in the body. To enhance the bioavailability of ginsenosides, diverse micro-/nano-sized delivery systems such as emulsions, polymeric particles, and vesicular systems have been investigated. The delivery systems improved the bioavailability of ginsenosides by enhancing solubility, permeability, and stability of the natural products. This mini-review aims to provide comprehensive information on the micro-/nano-sized delivery systems for increasing the bioavailability of ginsenosides, which may be helpful for designing better delivery systems to maximize the versatile therapeutic potential of ginsenosides.
목차
ABSTRACT
1. Introduction
2. Factors to consider for improving bioavailability of ginsenosides
3. Representative micro-/nano-sized delivery systems for improving bioavailability of ginsenosides
4. Conclusion
References
참고문헌 (90)
참고문헌 신청
[학술지(정기간행물)] - Wang CZ / 2006 / Steamed American ginseng berry: ginsenoside analyses and anticancer activities / J Agric Food Chem 54 : 9936 ~ 9942
[학술지(정기간행물)] - Park EK / 2005 / Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide / Biol Pharm Bull 28 : 652 ~ 656
[학술지(정기간행물)] - Rai D / 2003 / Anti-stress effects of Ginkgo biloba and Panax ginseng: a comparative study / J Pharmacol Sci 93 : 458 ~ 464
[학술지(정기간행물)] - Keum YS / 2000 / Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng / Cancer Lett 150 : 41 ~ 48
[학술지(정기간행물)] - Hasegawa H / 2004 / Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid / J Pharmacol Sci 95 : 153 ~ 157
[학술지(정기간행물)] - Park EK / 2005 / Inhibitory effect of ginsenoside Rb1 and compound K on NO and prostaglandin E2 biosyntheses of RAW264.7 cells induced by lipopolysaccharide / Biol Pharm Bull 28 : 652 ~ 656
[학술지(정기간행물)] - Rai D / 2003 / Anti-stress effects of Ginkgo biloba and Panax ginseng: a comparative study / J Pharmacol Sci 93 : 458 ~ 464
[학술지(정기간행물)] - Keum YS / 2000 / Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng / Cancer Lett 150 : 41 ~ 48
[학술지(정기간행물)] - Hasegawa H / 2004 / Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid / J Pharmacol Sci 95 : 153 ~ 157
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Simultaneous quantification of six nonpolar ginsenosides in white ginseng by reverse-phase high-performance liquid chromatography coupled with integrated pulsed amperometric detection
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Salting-out extraction of ginsenosides from the enzymatic hydrolysates of Panax quinquefolium based on ethanol/sodium carbonate system
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Microbial conversion of major ginsenosides in ginseng total saponins by Platycodon grandiflorum endophytes
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Synthesis of ginsenoside Rb₁-imprinted magnetic polymer nanoparticles for the extraction and cellular delivery of therapeutic ginsenosides
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Increased bioavailability of chrysin by preparing spray dried solid dispersion of chrysin
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UCI(KEPA) : I410-ECN-0101-2018-524-003161251