Identifying the role of neutrophil-to-lymphocyte ratio and platelets-to-lymphocyte ratio as prognostic markers in patients undergoing resection of pancreatic ductal adenocarcinoma

Alexandros Giakoustidis; Kyriakos Neofytou; Mafalda Costa Neves; Dimitrios Giakoustidis; Eleni Louri; David Cunningham; Satvinder Mudan

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저자정보: Alexandros Giakoustidis (The Royal Marsden Hospital) Kyriakos Neofytou (The Royal Marsden Hospital) Mafalda Costa Neves (The Royal Marsden Hospital) Dimitrios Giakoustidis (The Royal Marsden Hospital) Eleni Louri (The Royal London Hospital) David Cunningham (Faculty of Medicine, Imperial College) Satvinder Mudan (The Royal Marsden Hospital)

저널정보: 한국간담췌외과학회 Annals of Hepato-Biliary-Pancreatic Surgery 한국간담췌외과학회지 제22권 제3호

발행연도: 2018.8

수록면: 197 - 207 (11page)

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Backgrounds/Aims: It is important to point out that the identification of inflammation is an essential component of the pathogenesis and the progression of cancer. In this study, we analysed the neutrophil-to-lymphocyte ratio (NLR) and the platelets-to-lymphocyte ratio (PLR), with an overall survival (OS) in patients with pancreatic ductal adenocarcinoma (PDAC), who were treated with a resection following or not following a procedure of neoadjuvant chemotherapy/chemoradiation. We intended to identify the significance of the role of NLR and PLR, as prognostic markers in patients undergoing surgery for PDAC. Methods: There were 127 patients enrolled in the study. The NLR and PLR were calculated on the basis of the pre-treatment blood cell count. An NLR＞4 and a PLR ＞120 were considered to be elevated as measured. OS was analysed in relation to the NLR and PLR values, by using both the Kaplan-Meier and multivariate Cox-regression methods. Results: Both high the NLR and high PLR were associated with a decreased OS in the univariate analysis. In the multivariate analysis, the high NLR, but not the high PLR, was an independent predictor of a decreased OS. When we divided patients into three groups (group 1: normal both NLR and PLR, group 2: high NLR or high PLR, group 3: high both NLR and PLR), the three-years OS rates for these groups were 48%, 32%, 7% (p=0.001) respectively. Conclusions: It is noted that the pre-treatment NLR is an independent adverse prognostic factor, and considered to be superior to the PLR, in patients who undergo a resection for PDAC following or not neoadjuvant chemotherapy/chemoradiation.

#NLR #Pancreatic ductal adenocarcinoma #Inflammation #PLR #Prognostic factor

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