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논문 기본 정보

자료유형
학술저널
저자정보
Young Ho Lee (Korea University College of Medicine)
저널정보
대한류마티스학회 대한류마티스학회지 대한류마티스학회지 제25권 제3호
발행연도
2018.1
수록면
169 - 178 (10page)

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Objective. This study examined the relationship between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean platelet volume (MPV), and rheumatoid arthritis (RA), to establish a correlation among the NLR, PLR, and MPV and RA activity. Methods. Medline, Embase, and Cochrane were searched, and a meta-analysis was performed to compare the NLR, PLR, and MPV between RA patients and healthy controls. The correlation coefficients between NLR, PLR, and MPV and the Disease Activity Score 28 (DAS28) in the RA patients were examined. Results. Sixteen studies were included in this meta-analysis. NLR was significantly higher in the RA group (standardized mean difference [SMD], 0.800; 95% confidence interval [CI], 0.542∼1.058; p<0.001). Stratification according to ethnicity revealed a significantly elevated NLR in the RA group in Asian and Turkish populations (SMD, 95% CI: 0.994, 0.418∼1.519, p=0.001 and 0.695, 0.443∼0.948, p<0.001, respectively). Subgroup analysis revealed a significantly high NLR in RA, independent of the data type and adjustment for age and/or sex. PLR was also significantly higher in the RA group (SMD, 0.708; 95% CI, 0.401∼0.995; p<0.001), regardless of ethnicity, data type, and adjustment for age and/or sex. In addition, NLR and PLR were positively associated with the RA activity based on the DAS28 (correlation coefficient, 95% CI: 0.277, 0.190∼0.359, p<0.001 and 0.318, 0.197∼0.430, p<0.001, respectively). However, MPV showed no correlation with the RA activity (correlation coefficient, −0.095; 95% CI, −0.435 to 0.269; p=0.615). Conclusion. Meta-analysis showed that the NLR and PLR were significantly higher in the RA patients and positively but weakly correlated with the RA activity.

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