돌발성 난청의 예후 예측 인자로서 호중구-림프구 비율 및 혈소판-림프구 비율의 의미

이근익; 오세준; 최성원; 김선린; 공수근; 고의경

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자료유형: 학술저널

저자정보: 이근익 오세준 최성원 김선린 공수근 고의경

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제61권 제7호

발행연도: 2018.1

수록면: 333 - 340 (8page)

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Background and Objectives The cause of idiopathic sudden sensorineural hearing loss(ISSNHL) is still unclear, but recently, chronic inflammation and thrombosis have received attention. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) aresome of the markers that show the state of inflammation and ischemia, which are measuredroutinely in the complete blood cell count (CBC) test. The aim of this study were to investigatethe relevance of NLR and PLR with ISSNHL. Subjects and Method Enrolled in our retrospective analysis were 103 patients diagnosedwith ISSNHL. Blood samples were taken from the patients and hearing assessments were performed. NLR and PLR were calculated using the CBC results. Then the patients were dividedinto 4 groups using Sigel’s criteria according to their response to the treatment, which wereagain classified two groups, the “recovered” and “unrecovered” group. Results NLR, PLR, and neutrophil values of the unrecovered group were significantly higherthan the recovered group (p=0.002, p=0.009, and p=0.038, respectively). On the other hand,lymphocyte values were significantly higher in the recovered group (p=0.007). After adjustmentin a multivariate logistic regression analysis, NLR was associated with the recovery ofISSNHL (Odds ratio=1.290, p=0.042). In addition, NLR and PLR values were also significantlydifferent between the groups classified by the Sigel’s criteria (p=0.009 and p=0.029, respectively). Conclusion PLR values may be useful in predicting hearing recovery after treatment in patientswith ISSNH. It is also expected to be a potential marker for predicting the prognosis and determiningfurther treatment options.

참고문헌 (52)

참고문헌 신청

Hughes GB / 1996 / Sudden sensorineural hearing loss / Otolaryngol Clin North Am 29(3):393~405

Mattox DE / 1977 / Natural history of sudden sensorineural hearing loss / Ann Otol Rhinol Laryngol 86(4 Pt 1):463~480

Merchant SN / 2008 / Sudden deafness: is it viral? / ORL J Otorhinolaryngol Relat Spec 70(1):52~60

Masuda M / 2012 / Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss / Otol Neurotol 33(7):1142~1150

Ryan AF / 2002 / Immune-mediated hearing loss: basic mechanisms and options for therapy / Acta Otolaryngol Suppl (548):38~43

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