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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,021 - 1,034 (14page)
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Objectives: The aim of this study was to investigate the effects of Gaejigayonggolmoryo-tang (GYT) on ulcerative colitis induced by dextran sodium sulfate (DSS) in mice.
Methods: Colitis was induced by free drinking of 5% DSS in six-week-old male ICR mice. The experimental groups were the sample group, the control group, and the normal group. The sample group was treated with GYT for three days after being was given 5% DSS for five days. The control group was given water, instead of GYT, for three days after the five days of 5% DSS. The normal group was untreated (not given 5% DSS), for comparison purposes.
Results: Cellular experiments showed that GYT inhibits the expression of the inflammatory enzymes COX-2 and iNOS, and the production of NO. Based on the primary cellular experiments, the effects of GYT on ulcerative colitis induced by DSS of mouse tissues were investigated. GYT reduced tissue damage and apoptosis by inhibiting the expression of the inflammatory enzymes NF-κB p65, COX-2, and iNOS. In the cellular experiment, GYT was more effective in inhibiting the expression of COX-2 than in inhibiting the expression of iNOS. GYT was evidently effective in tissues in inhibiting the expression of COX-2.
Conclusions: Based on the results here, GYT may have therapeutic effects on ulcerative colitis induced by DSS. GYT is worthy of research and development as a COX-2 inhibitor and a potential drug for inflammatory bowel diseases from natural products. Further investigations for exact mechanisms will be needed.
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참고문헌 (32)
참고문헌 신청
Hengartmer MO / 2000 / The biochemistry of apoptosis / Nature 407(6805):770~776
Martín AR / 2003 / The cyclo-oxygenase-2 inhibitor, rofecoxib, attenuates mucosal damage due to colitis induced by trinitrobenzene sulphonic acid in rats / European J Pharmacology 481(2-3):281~291
/ 2006 / Korean Federation of Internal Medicine compilation Harrison’s Internal Medicine / Do Seo Publising MIP : 1937 ~ 1950
Department of gastrointestinal medicine Korean medicine / 2008 / gastrointestinal internal medicine / Gunja Publishing Co., Ltd : 365 ~
He ZD / 2005 / Authentication and quantitative analysis on the chemical profile of cassia bark(cortex cinnamomi) by high-pressure liquid chromatography / J Agric Food Chem 5
Martín AR / 2003 / The cyclo-oxygenase-2 inhibitor, rofecoxib, attenuates mucosal damage due to colitis induced by trinitrobenzene sulphonic acid in rats / European J Pharmacology 481(2-3):281~291
/ 2006 / Korean Federation of Internal Medicine compilation Harrison’s Internal Medicine / Do Seo Publising MIP : 1937 ~ 1950
Department of gastrointestinal medicine Korean medicine / 2008 / gastrointestinal internal medicine / Gunja Publishing Co., Ltd : 365 ~
He ZD / 2005 / Authentication and quantitative analysis on the chemical profile of cassia bark(cortex cinnamomi) by high-pressure liquid chromatography / J Agric Food Chem 5
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