Protective Effects of Plathymenia reticulata and Connarus favosus Aqueous Extracts against Cadmium- and Mercury-Induced Toxicities

Kewin Gombeau; Ricardo Bezerra de Oliveira; Sandra Layse Ferreira Sarrazin; Rosa Helena Veras Mourão; Jean-Paul Bourdineaud

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자료유형: 학술저널

저자정보: Kewin Gombeau (University of Bordeaux) Ricardo Bezerra de Oliveira (Federal University of Western Pará - UFOPA) Sandra Layse Ferreira Sarrazin (Federal University of Western Pará - UFOPA) Rosa Helena Veras Mourão (Federal University of Western Pará - UFOPA) Jean-Paul Bourdineaud (University of Bordeaux)

저널정보: 한국독성학회 Toxicological Research Toxicological Research Vol.35 No.1

발행연도: 2019.1

수록면: 24 - 36 (13page)

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The extracts of Plathymenia reticulata and Connarus favosus are widely used in the folk medicine. The potential protective effects of these extracts have been evaluated against cadmium in the yeast Saccharomyces cerevisiae, and against mercurial contamination in zebrafish Danio rerio. In yeast, both extracts efficiently protected the Δycf1 mutant strain exposed to cadmium chloride restoring the growth, the expression of stress-response genes and decreasing the level of oxidative stress. In zebrafish, the supplementation of methylmercury-contaminated diet with both plant extracts similarly protected fish through the suppression of the methylmercury-induced lipid peroxidation, decrease of acetylcholinesterase activity, and restoring the expression levels of stress-response genes. This study particularly demonstrates the protective potential of both aqueous extracts against methylmercury, and could represent an interesting alternative for the Amazonian fish-eating communities to cope with the impact of chronic exposure to contaminated diets.

#Plant extract #Methylmercury #Cadmium #Saccharomyces cerevisiae #Danio rerio #Oxidative stress

참고문헌 (45)

참고문헌 신청

Bieski, I.G. / 2015 / Ethnobotanical study of medicinal plants by population of Valley of Juruena Region, Legal Amazon, Mato Grosso, Brazil / J. Ethnopharmacol 173:383~423

Breitbach, U.B. / 2013 / Amazonian Brazilian medicinal plants described by C.F.P. von Martius in the 19th century / J. Ethnopharmacol 147:180~189

De Medeiros, P.M. / 2013 / Patterns of medicinal plant use by inhabitants of Brazilian urban and rural areas: a macroscale investigation based on available literature / J. Ethnopharmacol 150:729~746

Pedrollo, C.T. / 2016 / Medicinal plants at Rio Jauaperi, Brazilian Amazon: ethnobotanical survey and environmental conservation / J. Ethnopharmacol 186:111~124

Moura, V.M. / 2016 / The inhibitory potential of the condensed-tannin-rich fraction of Plathymenia reticulata Benth. (Fabaceae) against Bothrops atrox envenomation / J. Ethnopharmacol 183:136~142

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