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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 75 - 81 (7page)
이용수
초록· 키워드
오류제보하기
Tartrazine (TAZ) is one of the most commonly used artificial dyes for foods and drugs. We determined the effect of TAZ on fetal development by examining morphological, visceral, and skeletal malformations in rat fetuses following daily oral administration of TAZ to pregnant Wistar rats at the 6th-15th day of gestation. TAZ at 0.45 and 4.5 mg/kg induced 6.0 and 7.1% fetal resorptions, as well as 10.0 and 10.5% fetal mortality, respectively. Fetal body weight and length were significantly lower in the groups treated with TAZ at 0.45 (3.97 ± 0.21 g and 27.3 ± 0.54 mm, respectively) and 4.5 mg/kg (3.48 ± 0.15 g and 23.22 ± 1.02 mm, respectively) than in the control group (4.0 ± 0.15 g and 30.01 ± 0.42 mm, respectively). TAZ at 0.45 and 4.5 mg/kg induced hepatic damage (20 and 33.3%, respectively), dark brown pigmentation due to hemosiderin in the splenic parenchyma (16.7 and 21.7%, respectively), as well as destructed and necrotic renal tubules (16.7 and 26.7%, respectively) in the fetuses. Moreover, TAZ at 0.45 and 4.5 mg/kg caused one or more missing coccygeal vertebrae (20 and 40%, respectively), missing sternebrae (6 and 10%, respectively), missing hind limbs (24 and 4%, espectively), and irregular ribs (16 and 20, respectively) in the fetuses. We concluded that TAZ has embryotoxic and teratogenic potentials in rats.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (54)
참고문헌 신청
Tanaka, T. / 2008 / Effects of tartrazine on exploratory behavior in a three-generation toxicity study in mice / Reprod. Toxicol 26:156~163
Allam, K.V. / 2011 / Colorants-the cosmetics for the pharmaceutical dosage forms / Int. J. Pharm. Pharm. Sci 3:9
Mehedi, N. / 2009 / Reproductive toxicology of tartrazine (FD and C Yellow No. 5) in Swiss albino mice / Am. J. Pharmacol. Toxicol 4:130~135
Khayyat, L. / 2017 / Tartrazine induces structural and functional aberrations and genotoxic effects in vivo / PeerJ 5:e3041
Amin, K. / 2010 / Effect of food azo dyes tartrazine and carmoisine on biochemical parameters related to renal, hepatic function and oxidative stress biomarkers in young male rats / Food Chem. Toxicol 48:2994~2999
Allam, K.V. / 2011 / Colorants-the cosmetics for the pharmaceutical dosage forms / Int. J. Pharm. Pharm. Sci 3:9
Mehedi, N. / 2009 / Reproductive toxicology of tartrazine (FD and C Yellow No. 5) in Swiss albino mice / Am. J. Pharmacol. Toxicol 4:130~135
Khayyat, L. / 2017 / Tartrazine induces structural and functional aberrations and genotoxic effects in vivo / PeerJ 5:e3041
Amin, K. / 2010 / Effect of food azo dyes tartrazine and carmoisine on biochemical parameters related to renal, hepatic function and oxidative stress biomarkers in young male rats / Food Chem. Toxicol 48:2994~2999
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UCI(KEPA) : I410-ECN-0101-2019-513-000294532