메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Hirozumi Sano (Department of Hematology/Oncology for Children and Adolescents Sapporo Hokuyu Hospital Sapporo Japa) Ryoji Kobayashi (Department of Hematology/Oncology for Children and Adolescents Sapporo Hokuyu Hospital Sapporo Japa) Satoru Matsushima (Department of Hematology/Oncology for Children and Adolescents Sapporo Hokuyu Hospital Sapporo Japa) Daiki Hori (Department of Hematology/Oncology for Children and Adolescents Sapporo Hokuyu Hospital Sapporo Japa) Masato Yanagi (Department of Hematology/Oncology for Children and Adolescents Sapporo Hokuyu Hospital Sapporo Japa) Koya Kodama (Department of Hematology/Oncology for Children and Adolescents Sapporo Hokuyu Hospital Sapporo Japa) Daisuke Suzuki (Department of Hematology/Oncology for Children and Adolescents Sapporo Hokuyu Hospital Sapporo Japa) Kunihiko Kobayashi (Department of Hematology/Oncology for Children and Adolescents Sapporo Hokuyu Hospital Sapporo Japa)
저널정보
대한소아혈액종양학회 Clinical Pediatric Hematology-Oncology Clinical Pediatric Hematology-Oncology Vol.28 No.2
발행연도
2021.10
수록면
75 - 83 (9page)
DOI
10.15264/cpho.2021.28.2.75

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Background: Febrile neutropenia (FN) remains an important complication in pedia-tric cancer patients. The present study compared the efficacy of meropenem (MEPM) and piperacillin/tazobactam (PIPC/TAZ) with or without intravenous immunoglobulin (IVIG) as second-line therapy for FN in pediatric patients.Methods: As first-line treatment for FN, 394 episodes in 99 patients were randomly assigned to receive PIPC/TAZ (360 mg/kg/day, maximum 18 g/day) or MEPM (120 mg/ kg/day, maximum 3 g/day). Eighty-four episodes in 42 patients were judged as fail-ures, and, thus, were enrolled for second-line treatment. In second-line treatment, antibiotics were switched to MEPM or PIPC/TAZ, and episodes were further random-ized for treatment with or without concomitant IVIG at 100 mg/kg/day (maximum 5 g/day) for 3 consecutive days.Results: The total success rate of second-line treatment was 50.0% (52.0% in PIPC/ TAZ and 47.2% in MEPM with or without IVIG, P=0.826). The success rates of patients treated with (IVIG+ group) and without IVIG (IVIG? group) were 53.8 and 46.7%, respectively (P=0.662). In the IVIG+ group, the success rate of patients younger than 8 years old was 78.6%, which was significantly higher than that of those aged 8 years and older (40.0%, P=0.043).Conclusion: PIPC/TAZ and MEPM were equally effective as second-line treatment. Concomitant IVIG was also effective, particularly in patients younger than 8 years.
#Meropenem #Piperacillin/Tazobactam #Immunoglobulin #Febrile neutropenia #Second-line treatment

목차

등록된 정보가 없습니다.

참고문헌 (21)

참고문헌 신청
Hann I / 1997 / A comparison of outcome from febrile neutropenic episodes in children compared with adults: results from four EORTC studies. International Antimicrobial Therapy Cooperative Group (IATCG) of the European Organization for Research and Treatment of Cancer (EORTC) / Br J Haematol 99:580~588 google schola Viscoli C / 1991 / Ceftazidime plus amikacin versus ceftazidime plus vancomycin as empiric therapy in febrile neutropenic children with cancer / Rev Infect Dis 13:397~404 google schola Kobayashi R / 2014 / Effect of meropenem with or without immunoglobulin as second-line therapy for pediatric febrile neutropenia / Pediatr Int 56:526~529 google schola Kobayashi R / 2018 / Meropenem versus piperacillin/tazobactam with or without immunoglobulin as second-line therapy for febrile neutropenia in pediatric patients / J Microbiol Immunol Infect 51:473~477 google schola Kobayashi R / 2021 / Meropenem versus piperacillin/tazobactam for febrile neutropenia in pediatric patients : efficacy of piperacillin/tazobactam as a 1-h drip infusion four times a day / Int J Hematol 113:430~435 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0