메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색
질문

논문 기본 정보

자료유형
학술저널
저자정보
최근훈 (경희대학교) 장래근 (경희대학교) 송영주 (경희대학교) 정유진 (경희대학교) 박현 (경희대학교)
저널정보
한국체육과학회 한국체육과학회지 한국체육과학회지 제28권 제3호 (자연과학 편)
발행연도
2019.6
수록면
763 - 774 (12page)
DOI
10.35159/kjss.2019.06.28.3.763

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색
질문

초록· 키워드

오류제보하기
Comparison of the level of bio-molecular components related with the working of GABA from reactive astrocytes through different types of exercise was performed. For the exercise of STZ induced AD rats activity wheel was used for voluntary exercise and treadmill was used for forced exercise for 6 weeks. To equalize the amount of exercise, the voluntary exercise was performed ahead, and then the forced exercise was given. For the analysis, hippocampus, astrocytes around hippocampus, and blood were used. Cognitive function was evaluated with the radial-arm maze and step-down avoidance apparatus. Exercise groups showed a significant improving compared to non-exercise group(p<.05). GFAP expression was significantly decreased in exercise groups, and the lowest value showed in the voluntary exercise group(p<.001). In GABA, analogous pattern to GFAP was observed. Corticosterone level, forced exercise showed an increase (p<.05), while voluntary exercise showed a decrease compared to non-exercise STZ group(p<.01). The expression of SIRT1 protein showed no significant difference between non-exercise groups, however voluntary exercise group showed a significant increase compared to non-exercise group and to forced exercise group(p<.001). With these results, we were able to assume that exercise can reduce the conversion of astrocytes to reactive form and can drop the GABA concentration with an increase of SIRT1 protein in the brain. It may be interpreted as that any kind of exercise could be beneficial to AD. However, a meaningful difference exist between the forced and the voluntary type of exercise on their effects on GABA and stress in AD subjects. Results made us to assure that properly programmed exercise should be developed in consideration of the specific disease as well as AD. We also can suggest that well-designed human studies on memory impairment in AD with specifically designed exercise programs reflect characteristics of exercise as forced or voluntary type are needed to clarify this matter.

목차

Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과
Ⅳ. 논의
Ⅴ. 결론
참고문헌

참고문헌 (40)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

이 논문과 함께 이용한 논문

최근 본 자료

전체보기

댓글(0)

0

UCI(KEPA) : I410-ECN-0101-2019-692-000878189