지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 236 - 243 (8page)
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초록· 키워드
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Background/Aims: Colonoscopy and computed tomography (CT) are used primarily to exclude organic diseases in patientswith irritable bowel syndrome (IBS), rather than to assess the pathophysiology of IBS. We aimed to evaluate colonic dysmotilityand morphology in Japanese patients with IBS. Methods: One hundred eighty-four patients with IBS and 49 asymptomaticcontrols who underwent colonoscopy in combination with CT colonography or barium enema were retrospectively reviewedbetween 2008 and 2012. Water-aided colonoscopy was performed without sedation by a single endoscopist. The durationand pattern of colonic movement and cecal intubation time were recorded. To assess colonic morphology, barium enemaor CT colonography were performed immediately after colonoscopy. Results: Colonic dysmotility was more frequent in theIBS group (28.8% vs. 2.0% in controls, P <0.001), especially in cases of IBS with diarrhea (IBS-D) (IBS with constipation [IBS-C]28.8% vs. IBS-D 60.0% vs. mixed IBS [IBS-M] 5.1%, P <0.001). Colonic morphological abnormality was more frequent in the IBSgroup than in the control group (77.7% vs. 24.5%, P <0.001), especially in IBS-M and IBS-C groups (IBS-C 77.5% vs. IBS-D 48.9%vs. IBS-M 100%, P <0.001). Most patients with IBS with colonic dysmotility had experienced stress related to their symptoms. Cecal intubation time was significantly longer in the IBS group than in the control group (12.1±6.9 minutes vs. 4.6±1.9 minutes,P <0.001). Conclusions: Unsedated colonoscopy, combined with radiographic findings, can detect colonic dysmotility andmorphological abnormality. Technical difficulties observed during cecal intubation may partially explain the pathophysiologyof IBS.
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참고문헌 (31)
참고문헌 신청
Gralnek IM / 2000 / The impact of irritable bowel syndrome on health-related quality of life / Gastroenterology 119:654~660
Drossman DA. / 2006 / The functional gastrointestinal disorders and the Rome III process / Gastroenterology 130:1377~1390
Lovell RM / 2012 / Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis / Clin Gastroenterol Hepatol 10:712.e4~721.e4
Fukudo S / 1987 / Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress on irritable bowel syndrome / Tohoku J Exp Med 151:373~385
Kim ES / 2010 / Colonoscopy as an adjunctive method for the diagnosis of irritable bowel syndrome: focus on pain perception / J Gastroenterol Hepatol 25:1232~1238
Drossman DA. / 2006 / The functional gastrointestinal disorders and the Rome III process / Gastroenterology 130:1377~1390
Lovell RM / 2012 / Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis / Clin Gastroenterol Hepatol 10:712.e4~721.e4
Fukudo S / 1987 / Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress on irritable bowel syndrome / Tohoku J Exp Med 151:373~385
Kim ES / 2010 / Colonoscopy as an adjunctive method for the diagnosis of irritable bowel syndrome: focus on pain perception / J Gastroenterol Hepatol 25:1232~1238
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