지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.4
- 발행연도
- 2018.1
- 수록면
- 628 - 642 (15page)
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초록· 키워드
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Background/Aims A Subset of patients with irritable bowel syndrome (IBS) may have mild inflammation due to immune activation. Toll-like receptors (TLRs) and cytokines may cause intestinal inflammation. We studied their expression in relation to gut microbiota. Methods Expression of TLRs and cytokines was assessed in 47 IBS patients (Rome III) and 25 controls using quantitative real-time polymerase chain reaction. Immunohistochemistry was further performed to confirm the expression of TLR-4 and TLR-5. Results Of 47 patients with IBS, 20 had constipation (IBS-C), 20 diarrhea (IBS-D), and 7 unclassified (IBS-U). The mRNA levels of TLR-4 and TLR-5 were up-regulated in IBS patients than controls (P = 0.013 and P < 0.001, respectively). Expression of TLR-4 and TLR-5 at protein level was 4.2-folds and 6.6-folds higher in IBS-D than controls. The mRNA levels of IL-6 (P = 0.003), C-X-C motif chemokine ligand 11 (CXCL-11) (P < 0.001) and C-X-C motif chemokine receptor 3 (CXCR-3) (P < 0.001) were higher among IBS patients than controls. Expression of IL-6 (P = 0.002), CXCL-11 (P < 0.001), and CXCR-3 (P < 0.001) were up-regulated and IL-10 (P = 0.012) was down-regulated in IBS-D patients than controls. Positive correlation was seen between TLR-4 and IL-6 (P = 0.043), CXCR-3, and CXCL-11 (P = 0.047), and IL-6 and CXCR-3 (P = 0.003). Stool frequency per week showed positive correlation with mRNA levels of TLR-4 (P = 0.016) and CXCR-3 (P = 0.005), but inversely correlated with IL-10 (P = 0.002). Copy number of Lactobacillus (P = 0.045) and Bifidobacterium (P = 0.011) showed correlation with IL-10 in IBS-C, while Gram-positive (P = 0.031) and Gram-negative bacteria (P = 0.010) showed correlation with CXCL-11 in IBS-D patients. Conclusions Altered immune activation in response to dysbiotic microbiota may promote intestinal inflammation in a subset of patients with IBS.
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등록된 정보가 없습니다.
참고문헌 (5)
참고문헌 신청
Uday C Ghoshal / 2015 / Development, Translation and Validation of Enhanced Asian Rome III Questionnaires for Diagnosis of Functional Bowel Diseases in Major Asian Languages: A Rome Foundation-Asian Neurogastroenterology and Motility Association Working Team Report / Journal of Neurogastroenterology and Motility (JNM) 21(1):83~92
진선희 / 2010 / Activation of Toll-like Receptors 1, 2, 4, 5, and 7 on Human Melanocytes Modulate Pigmentation / Annals of Dermatology 22(4):486~489
Stanislawowski M / 2009 / Decreased toll-like receptor-5 (TLR-5) expression in the mucosa of ulcerative colitis patients / J Physiol Pharmacol 60(suppl 4):71~75
Wen-Jing Liang / 2016 / Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome / Gut and Liver 10(3):382~390
Wells JM / 2011 / Epithelial crosstalk at the microbiota-mucosal interface / Proc Natl Acad Sci USA 108(suppl 1):4607~4614
진선희 / 2010 / Activation of Toll-like Receptors 1, 2, 4, 5, and 7 on Human Melanocytes Modulate Pigmentation / Annals of Dermatology 22(4):486~489
Stanislawowski M / 2009 / Decreased toll-like receptor-5 (TLR-5) expression in the mucosa of ulcerative colitis patients / J Physiol Pharmacol 60(suppl 4):71~75
Wen-Jing Liang / 2016 / Tryptase and Protease-Activated Receptor 2 Expression Levels in Irritable Bowel Syndrome / Gut and Liver 10(3):382~390
Wells JM / 2011 / Epithelial crosstalk at the microbiota-mucosal interface / Proc Natl Acad Sci USA 108(suppl 1):4607~4614
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