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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 502 - 508 (7page)
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초록· 키워드
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Inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis, are chronic inflammatory conditions affecting the gastrointestinal tract with variable presentations and disease courses. The cause of IBD is unknown, but it is hypothesized that individuals with a genetic predisposition to disease develop an aberrant immune response to environmental triggers. Evidence suggests that microbiota residing in the gastrointestinal tract play an important role in the development and perpetuation of the disease. In this review, we discuss the role of microbes in the development of a healthy gut, their role in the development of diseases in general, and their role in the development of IBD. Advances in molecular technologies and bioinformatics will continue to further our insight into the structure of the microbial community, the function of the microbial community as a whole, and the interaction of this community with the host immune system. The latter two are crucial to understanding the role of microbes in IBD. The field has advanced significantly in recent years, and the future is very promising as we begin to elucidate the microbial basis of IBD.
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참고문헌 (40)
참고문헌 신청
Loftus EV Jr / 2004 / Clinical epidemiology of inflammatory bowel disease:incidence, prevalence, and environmental influences / Gastroenterology 126:1504~1517
Lee YK / 2010 / Has the microbiota played a critical role in the evolution of the adaptive immune system? / Science 330:1768~1773
Devkota S / 2012 / Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/-mice / Nature 487:104~108
Dalal SR / 2014 / The microbial basis of inflammatory bowel diseases / J Clin Invest 124:4190~4196
Arrieta MC / 2014 / The intestinal microbiome in early life: health and disease / Front Immunol 5:427
Lee YK / 2010 / Has the microbiota played a critical role in the evolution of the adaptive immune system? / Science 330:1768~1773
Devkota S / 2012 / Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/-mice / Nature 487:104~108
Dalal SR / 2014 / The microbial basis of inflammatory bowel diseases / J Clin Invest 124:4190~4196
Arrieta MC / 2014 / The intestinal microbiome in early life: health and disease / Front Immunol 5:427
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