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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 588 - 595 (8page)
- DOI
- https://doi.org/10.5124/jkma.2021.64.9.588
이용수
초록· 키워드
오류제보하기
Background: The prevalence of inflammatory bowel diseases (IBD) has been rapidly increasing over the past several decades in Korea. IBD appears to be resulted from inappropriate and chronic activation of the mucosal immune system driven by stimuli such as intestinal microbiota and various environmental factors in genetically susceptible individuals.
Current Concepts: Recent advances in next-generation sequencing technology have identified alterations in the composition and function of the intestinal microbiota in individuals with IBD. Dysbiosis in patients with IBD is characterized by decreased bacterial diversity combined with an expansion of putative aggressive species and a reduction in protective species. Altered microbial composition and function in IBD correlates with increased immune stimulation, epithelial dysfunction, or enhanced mucosal permeability. Thus, dysbiosis may play an essential role in the pathogenesis of IBD.
Discussion and Conclusion: Although it is currently unclear whether dysbiosis is a cause or consequence of intestinal inflammation in IBD, several microbial-based and microbial-targeted therapies have yielded promising early results.
목차
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참고문헌 (45)
참고문헌 신청
Emiko Mizoguchi / 2020 / Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models / Intestinal research 18(2):151~167
유준환 / 2020 / Fibrostenotic strictures in Crohn’s disease / Intestinal research 18(4):379~401
Matsuoka K / 2015 / The gut microbiota and inflammatory bowel disease / Semin Immunopathol 37:47~55
Gilbert JA / 2016 / Microbiome-wide association studies link dynamic microbial consortia to disease / Nature 535:94~103
Forbes JD / 2016 / Microbiome survey of the inflamed and noninflamed gut at different compartments within the gastrointestinal tract of inflammatory bowel disease patients / Inflamm Bowel Dis 22:817~825
유준환 / 2020 / Fibrostenotic strictures in Crohn’s disease / Intestinal research 18(4):379~401
Matsuoka K / 2015 / The gut microbiota and inflammatory bowel disease / Semin Immunopathol 37:47~55
Gilbert JA / 2016 / Microbiome-wide association studies link dynamic microbial consortia to disease / Nature 535:94~103
Forbes JD / 2016 / Microbiome survey of the inflamed and noninflamed gut at different compartments within the gastrointestinal tract of inflammatory bowel disease patients / Inflamm Bowel Dis 22:817~825
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