지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
오류제보하기
Oral anticoagulant-associated intracerebral hemorrhage (OAC-ICH) accounts for nearly 20% of all ICH. The number of patients with an indication for oral anticoagulant therapy (OAT) increases with increasing age. OAT became less complicate with the introduction of non-vitamin K oral anticoagulants (NOAC) OAT because of easier handling, favorable risk-benefit profile, reduced rates of ICH compared to vitamin K antagonists and no need for routine coagulation testing. Consequently, despite a better safety profile of NOAC the number of patients with OAC-ICH will increase. The mortality and complication rates of OAC-ICH are high and therefore they are the most feared complication of OAT. Immediate normalization of coagulation is the main goal and therefore knowledge of pharmacodynamics and coagulation status is essential. Laboratory measurements of anticoagulant activity in NOAC patients is challenging as specific tests are not widely available. More accessible tests such as the prothrombin time and activated partial thromboplastin time have important limitations. In dabigatran-associated ICH 5 g Idarucizumab should be administered. In rivaroxaban and apixaban-associated ICHs administration of andexanet alpha should be considered. Prothrombin complex concentrate may be considered if andexanet alpha is not available or in case of an ICH associated with edoxaban.
목차
등록된 정보가 없습니다.
참고문헌 (75)
참고문헌 신청
Sacco S / 2009 / Incidence and 10-year survival of intracerebral hemorrhage in a population-based registry / Stroke 40:394~399
Flaherty ML / 2010 / Anticoagulant-associated intracerebral hemorrhage / Semin Neurol 30:565~572
Alotaibi GS / 2016 / Secular trends in incidence and mortality of acute venous thromboembolism: the AB-VTE population-based study / Am J Med 129:879
Writing Group Members / 2016 / Heart disease and stroke statistics-2016 update: a report from the American heart association / Circulation 133:e38~e360
Steinberg BA / 2017 / International trends in clinical characteristics and oral anticoagulation treatment for patients with atrial fibrillation: results from the GARFIELD-AF, ORBIT-AF I, and ORBITAF II registries / Am Heart J 194:132~140
Flaherty ML / 2010 / Anticoagulant-associated intracerebral hemorrhage / Semin Neurol 30:565~572
Alotaibi GS / 2016 / Secular trends in incidence and mortality of acute venous thromboembolism: the AB-VTE population-based study / Am J Med 129:879
Writing Group Members / 2016 / Heart disease and stroke statistics-2016 update: a report from the American heart association / Circulation 133:e38~e360
Steinberg BA / 2017 / International trends in clinical characteristics and oral anticoagulation treatment for patients with atrial fibrillation: results from the GARFIELD-AF, ORBIT-AF I, and ORBITAF II registries / Am Heart J 194:132~140
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