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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 559 - 564 (6page)
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We investigated the effects of mangiferin on the expression and activity of metalloproteinase (MMP)-9 and the invasion of tumor necrosis factor (TNF)-α-stimulated human LNCaP prostate carcinoma cells. Reverse-transcription polymerase chain reaction (RT-PCR) and western blot analysis showed that mangiferin significantly reversed TNF-α-induced mRNA and protein expression of MMP-9 expression. Zymography data confirmed that stimulation of cells with TNF-α significantly increased MMP-9 activity. However, mangiferin substantially reduced the TNF-α-induced activity of MMP-9. Additionally, a matrigel invasion assay showed that mangiferin significantly reduced TNF-α-induced invasion of LNCaP cells. Compared to untreated controls, TNF-α-stimulated LNCaP cells showed a significant increase in nuclear factor-κB (NF-κB) luciferase activity. However, mangiferin treatment markedly decreased TNF-α-induced NF-κB luciferase activity. Furthermore, mangiferin suppressed nuclear translocation of the NF-κB subunits p65 and p50. Collectively, our results indicate that mangiferin is a potential anti-invasive agent that acts by suppressing NF-κB-mediated MMP-9 expression.
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참고문헌 (28)
참고문헌 신청
Nelson AR / 2000 / Matrix metalloproteinases: biologic activity and clinical implications / J Clin Oncol 18:1135~1149
Visse R / 2003 / Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry / Circ Res 92:827~839
Andela VB / 2003 / NFkappaB : a pivotal transcription factor in prostate cancer metastasis to bone / Clin Orthop Relat Res 415:75~85
Vayalil PK / 2004 / Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NFκB / Carcinogenesis 25:987~995
Diaz-Meco MT / 2008 / Akt regulation and lung cancer: a novel role and mechanism of action for the tumor suppressor Par-4 / Cell Cycle 7:2817~2820
Visse R / 2003 / Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry / Circ Res 92:827~839
Andela VB / 2003 / NFkappaB : a pivotal transcription factor in prostate cancer metastasis to bone / Clin Orthop Relat Res 415:75~85
Vayalil PK / 2004 / Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NFκB / Carcinogenesis 25:987~995
Diaz-Meco MT / 2008 / Akt regulation and lung cancer: a novel role and mechanism of action for the tumor suppressor Par-4 / Cell Cycle 7:2817~2820
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