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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 584 - 589 (6page)
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Intercellular adhesion molecule-1 (ICAM-1), which is induced by tumor necrosis factor (TNF)-α, contributes to the entry of immune cells into the site of inflammation in the skin. Here, we show that protein tyrosine phosphatase non-receptor type 21 (PTPN21) negatively regulates ICAM-1 expression in human keratinocytes. PTPN21 expression was transiently induced after stimulation with TNF-α. When overexpressed, PTPN21 inhibited the expression of ICAM-1 in HaCaT cells but PTPN21 C1108S, a phosphatase activity-inactive mutant, failed to inhibit ICAM-1 expression. Nuclear factor-κB (NF-κB), a key transcription factor of ICAM-1 gene expression, was inhibited by PTPN21, but not by PTPN21 C1108S. PTPN21 directly dephosphorylated phospho-inhibitor of κB (IκB)-kinase β (IKKβ) at Ser177/181. This dephosphorylation led to the stabilization of IκBα and inhibition of NF-κB activity. Taken together, our results suggest that PTPN21 could be a valuable molecular target for regulation of inflammation in the skin by dephosphorylating p-IKKβ and inhibiting NF-κB signaling.
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참고문헌 (21)
참고문헌 신청
Ali S / 2004 / Signal transduction via the NF-kappaB pathway: a targeted treatment modality for infection, inflammation and repair / Cell Biochem Funct 22 : 67 ~ 79
Bahar-Shany K / 2010 / Upregulation of MMP-9 production by TNFalpha in keratinocytes and its attenuation by vitamin D / J Cell Physiol 222 : 729 ~ 737
Barisic S / 2008 / Identification of PP2A as a crucial regulator of the NF-kappaB feedback loop: its inhibition by UVB turns NF-kappaB into a
Barr AJ / 2009 / Large-scale structural analysis of the classical human protein tyrosine phosphatome / Cell 136 : 352 ~ 363
Cardone L / 2004 / Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling / Mol Cell Biol 24 : 4613 ~ 4626
Bahar-Shany K / 2010 / Upregulation of MMP-9 production by TNFalpha in keratinocytes and its attenuation by vitamin D / J Cell Physiol 222 : 729 ~ 737
Barisic S / 2008 / Identification of PP2A as a crucial regulator of the NF-kappaB feedback loop: its inhibition by UVB turns NF-kappaB into a
Barr AJ / 2009 / Large-scale structural analysis of the classical human protein tyrosine phosphatome / Cell 136 : 352 ~ 363
Cardone L / 2004 / Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling / Mol Cell Biol 24 : 4613 ~ 4626
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