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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 25 - 30 (6page)
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초록· 키워드
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In the central nervous system, viral infection can induce inflammation by up-regulating pro-inflammatory mediators that contribute to enhanced infiltration of immune cells into the central nervous areas. Celastrol is known to exert various regulatory functions, including anti-microbial activities. In this study, we investigated the regulatory effects and the mechanisms of action of celastrol against astrocytes activated with polyinosinic-polycytidylic acid (poly(I:C)), a synthetic dsRNA, as a model of pro-inflammatory mediated responses. Celastrol significantly inhibited poly(I:C)-induced expression of adhesion molecules, such as ICAM-1/VCAM-1, and chemokines, such as CCL2, CXCL8, and CXCL10, in CRT-MG human astroglioma cells. In addition, celastrol significantly suppressed poly(I:C)-induced activation of JNK MAPK and STAT1 signaling pathways. Furthermore, celastrol significantly suppressed poly(I:C)-induced activation of the NF-κB signaling pathway. These results suggest that celastrol may exert its regulatory activity by inhibiting poly(I:C)-induced expression of pro-inflammatory mediators by suppressing activation of JNK MAPK-STAT1/NF-κB in astrocytes.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
[학술지(정
Allison AC / 2001 / Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease / Prog Neuropsychopharmacol Biol Psychiatry 2
Arroyo DS / 2011 / Toll-like receptors are key players in neurodegeneration / Int Immunopharmacol 11 : 1415 ~ 1421
Bsibsi M / 2006 / Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators / Glia 53 : 688 ~ 695
Farina C / 2005 / Preferential expression and function of Toll-like receptor 3 in human astrocytes / J Neuroimmunol 159 : 12 ~ 19
Allison AC / 2001 / Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease / Prog Neuropsychopharmacol Biol Psychiatry 2
Arroyo DS / 2011 / Toll-like receptors are key players in neurodegeneration / Int Immunopharmacol 11 : 1415 ~ 1421
Bsibsi M / 2006 / Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators / Glia 53 : 688 ~ 695
Farina C / 2005 / Preferential expression and function of Toll-like receptor 3 in human astrocytes / J Neuroimmunol 159 : 12 ~ 19
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