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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 39 - 44 (6page)
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Exchange protein directly activated by cAMP (Epac) 2a-knockout (KO) mice exhibit accelerated diet-induced obesity and are resistant to leptin-mediated adipostatic signaling from the hypothalamus to adipose tissue, with sustained food intake. However, the impact of Epac2a deficiency on hypothalamic regulation of sympathetic nervous activity (SNA) has not been elucidated. This study was performed to elucidate the response of Epac2a-KO mice to dexamethasone-induced muscle atrophy and acute cold stress. Compared to age-matched wild-type mice, Epac2a-KO mice showed higher energy expenditures and expression of myogenin and uncoupling protein-1 in skeletal muscle (SM) and brown adipose tissue (BAT), respectively. Epac2a-KO mice exhibited greater endurance to dexamethasone and cold stress. In wild-type mice, exogenous leptin mimicked the responses observed in Epac2a-KO mice. This suggests that leptin-mediated hypothalamic signaling toward SNA appears to be intact in these mice. Hence, the potentiated responses of SM and BAT may be due to their high plasma leptin levels.
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참고문헌 (34)
참고문헌 신청
Seino S / 2005 / PKA-dependent and pka-independent pathways for cAMP-regulated exocytosis / Physiol Rev 85:1303~1342
Takahashi H / 2015 / Role of Epac2A/Rap1 signaling in interplay between incretin and sulfonylurea in insulin secretion / Diabetes 64:1262~1272
Schmidt M / 2013 / Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions / Pharmacol Rev 65:670~709
Hwang M / 2017 / Epac2a-null mice exhibit obesity-prone nature more susceptible to leptin resistance / Int J Obes 41:279~288
Huxing C / 2017 / The cellular and molecular bases of leptin and ghrelin resistance in obesity / Nat Rev Endocrinol 13:338~351
Takahashi H / 2015 / Role of Epac2A/Rap1 signaling in interplay between incretin and sulfonylurea in insulin secretion / Diabetes 64:1262~1272
Schmidt M / 2013 / Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions / Pharmacol Rev 65:670~709
Hwang M / 2017 / Epac2a-null mice exhibit obesity-prone nature more susceptible to leptin resistance / Int J Obes 41:279~288
Huxing C / 2017 / The cellular and molecular bases of leptin and ghrelin resistance in obesity / Nat Rev Endocrinol 13:338~351
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