지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 12 (12page)
이용수
초록· 키워드
오류제보하기
This study was performed to investigate the signaling pathway that mediates cyclic AMP (cAMP)-induced inhibition of histone deacetylase 8 (HDAC8) degradation, and the effect and underlying mechanisms of the resulting increase in HDAC8 expression on cisplatin-induced apoptosis in lung cancer cells. cAMP signaling increased HDAC8 expression via a protein kinase A (PKA)- independent pathway in H1299 non-small cell lung cancer cells. However, treatment with a selective activator of an exchange protein that was activated by cAMP (Epac) increased HDAC8 expression, and Epac2 inhibition abolished the isoproterenol (ISO)-induced increase in HDAC8 expression. ISO and the Epac activator activated Rap1, and Rap1A activation increased HDAC8 expression; moreover, inhibition of Rap1A with a dominant negative Rap1A or by shRNA-mediated knockdown abolished the ISO-induced increase in HDAC8 expression. Activation of cAMP signaling and Rap1A decreased the activating phosphorylation of Akt. Akt inhibition with a pharmacological inhibitor or expression of a dominant negative Akt inhibited the MKK4/JNK pathway and increased HDAC8 expression. The Akt inhibitor-induced increase in HDAC8 expression was abolished by pretreatment with proteasomal or lysosomal inhibitors. The ISO treatment increased cisplatin-induced apoptosis, which was abolished by HDAC8 knockdown. Exogenous HDAC8 expression increased cisplatin-induced apoptosis and decreased TIPRL expression, and the knockdown of TIPRL increased the apoptosis of cisplatin-treated cells. The ISO treatment decreased cisplatin-induced transcription of the TIPRL gene in a HDAC8-dependent manner. In conclusion, the Epac–Rap1–Akt pathway mediates cAMP signaling-induced inhibition of JNK-dependent HDAC8 degradation, and the resulting HDAC8 increase augments cisplatin-induced apoptosis by repressing TIPRL expression in H1299 lung cancer cells.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Balasubramanian S / 2008 / A novel histone deacetylase 8(HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas / Leukemia 22 : 1026 ~ 1034
Barneda-Zahonero B / 2012 / Histone deacetylases and cancer / Mol Oncol 6 : 579 ~ 589
Buggy JJ / 2000 / Cloning and characterization of a novel human histone deacetylase, HDAC8 / Biochem J 350 : 199 ~ 205
Chakrabarti A / 2015 / HDAC8 : a multifaceted target for therapeutic interventions / Trends Pharmacol Sci 36 : 481 ~ 492
Fimia GM / 2001 / Cyclic AMP signalling / J Cell Sci 114 : 1971 ~ 1972
Barneda-Zahonero B / 2012 / Histone deacetylases and cancer / Mol Oncol 6 : 579 ~ 589
Buggy JJ / 2000 / Cloning and characterization of a novel human histone deacetylase, HDAC8 / Biochem J 350 : 199 ~ 205
Chakrabarti A / 2015 / HDAC8 : a multifaceted target for therapeutic interventions / Trends Pharmacol Sci 36 : 481 ~ 492
Fimia GM / 2001 / Cyclic AMP signalling / J Cell Sci 114 : 1971 ~ 1972
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Isoproterenol increases histone deacetylase 6 expression and cell migration by inhibiting ERKsignaling via PKA and Epac pathways in human lung cancer Cells
Experimental and Molecular Medicine
2016 .01
-
Role of histone deacetylase 2 and its posttranslational modifications in cardiac hypertrophy
BMB Reports
2015 .01
-
MicroRNA-22 negatively regulates LPS-induced inflammatory responses by targeting HDAC6 in macrophages
BMB Reports
2020 .01
-
Identification of HDAC9 as a viable therapeutic target for the treatment of gastric cancer
Experimental and Molecular Medicine
2019 .01
-
Histone deacetylase 3 promotes alveolar epithelial–mesenchymal transition and fibroblast migration under hypoxic conditions
Experimental and Molecular Medicine
2022 .07
-
Epac: new emerging cAMP-binding protein
BMB Reports
2021 .01
-
A short guide to histone deacetylases including recent progress on class II enzymes
Experimental and Molecular Medicine
2020 .02
-
Modulation of gene expression dynamics by co-transcriptional histone methylations
Experimental and Molecular Medicine
2017 .01
-
Fine-tuning of gene expression dynamics by the Set2-Rpd3S pathway
BMB Reports
2017 .01
-
Author Correction: PP2A negatively regulates the hypertrophic response by dephosphorylating HDAC2 S394 in the heart
Experimental and Molecular Medicine
2019 .01
-
A novel HDAC6 inhibitor, CKD-504, is effective in treating preclinical models of huntington’s disease
BMB Reports
2023 .03
-
A549 폐암 세포주에서 AMPK/Akt/mTOR 신호 경로를 통한 소나무 담쟁이덩굴 에탄올 추출물의 Apoptosis 유도효과
KSBB Journal
2019 .09
-
Epac2a-knockout mice are resistant to dexamethasone-induced skeletal muscle atrophy and short-term cold stress
BMB Reports
2018 .01
-
분쇄 효율에 따른 순환골재 분말 혼입 모르타르의 특성
한국구조물진단유지관리공학회 논문집
2019 .01
-
Effect of silica fume on mechanical properties of concrete containing recycled asphalt pavement
Structural Engineering and Mechanics, An Int＇l Journal
2017 .01
-
AGS위암세포에서 AMPK/Akt/GSK-3β 신호경로를 통한 삼채추출물의 항암효과
KSBB Journal
2018 .12
-
Resveratrol enhances cisplatin-induced apoptosis in human hepatoma cells via glutamine metabolism inhibition
BMB Reports
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0