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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 149 - 156 (8page)
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The well-known second messenger cyclic adenosine monophosphate (cAMP) regulates the morphology and physiology of neurons and thus higher cognitive brain functions. The discovery of exchange protein activated by cAMP (Epac) as a guanine nucleotide exchange factor for Rap GTPases has shed light on protein kinase A (PKA)-independent functions of cAMP signaling in neural tissues. Studies of cAMP-Epac-mediated signaling in neurons under normal and disease conditions also revealed its diverse contributions to neurodevelopment, synaptic remodeling, and neurotransmitter release, as well as learning, memory, and emotion. In this mini-review, the various roles of Epac isoforms, including Epac1 and Epac2, highly expressed in neural tissues are summarized, and controversies or issues are highlighted that need to be resolved to uncover the critical functions of Epac in neural tissues and the potential for a new therapeutic target of mental disorders.
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참고문헌 (60)
참고문헌 신청
de Rooij J / 2000 / Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs / J Biol Chem 275:20829~20836
Kawasaki H / 1998 / A family of cAMP-binding proteins that directly activate Rap1 / Science 282:2275~2279
Frische EW / 2010 / Rap1, a mercenary among the Ras-like GTPases / Dev Biol 340:1~9
Banerjee U / 2015 / Exchange protein directly activated by cAMP encoded by the mammalian rapgef3gene : structure, function and therapeutics / Gene 570:157~167
Hoivik EA / 2013 / DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms / PLoS One 8:e67925
Kawasaki H / 1998 / A family of cAMP-binding proteins that directly activate Rap1 / Science 282:2275~2279
Frische EW / 2010 / Rap1, a mercenary among the Ras-like GTPases / Dev Biol 340:1~9
Banerjee U / 2015 / Exchange protein directly activated by cAMP encoded by the mammalian rapgef3gene : structure, function and therapeutics / Gene 570:157~167
Hoivik EA / 2013 / DNA methylation of alternative promoters directs tissue specific expression of Epac2 isoforms / PLoS One 8:e67925
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