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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 128 - 133 (6page)
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Astrocytes play a critical role in normal brain functions and maintaining the brain microenvironment, and defects in astrocytogenesis during neurodevelopment could give rise to severe mental illness and psychiatric disorders. During neuro- embryogenesis, astrocytogenesis involves astrocytic differentiation of neural precursor cells (NPCs) induced by signals from ciliary neurotrophic factor (CNTF) or pituitary adenylate cyclase-activating peptide (PACAP). However, in contrast to the CNTF signaling pathway, the exact mechanism underlying astrocytic differentiation induced by PACAP is unknown. In the present study, we aimed to verify a signaling pathway specific to PACAP-induced astrocytogenesis, using exchange protein directly activated by cAMP2 (Epac2)-knockout mice. We found that PACAP could trigger astrocytic differentiation of NPCs via Epac2 activation and an increase in the intracellular calcium concentration via a calcium ion influx. Taken together, we concluded that astrocytogenesis stimulated by PACAP occurs through a novel signaling pathway independent from CNTF-JAK/STAT signaling, that is the well-known pathway of astrocytogenesis.
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참고문헌 (23)
참고문헌 신청
Wang DD / 2008 / The astrocyte odyssey / Prog Neurobiol 86:342~367
Park JK / 1999 / Bipotent cortical progenitor cells process conflicting cues for neurons, glia in a hierarchical manner / J Neurosci 19:10383~10389
Bonni A / 1997 / Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway / Science 278:477~483
Vaudry D / 2009 / Pituitary adenylate cyclase-activating polypeptide, its receptors:20 years after the discovery / Pharmacol Rev 61:283~357
Breckler M / 2011 / Rap-linked cAMP signaling Epac proteins: compartmentation, functioning, disease implications / Cell Signal 23:1257~1266
Park JK / 1999 / Bipotent cortical progenitor cells process conflicting cues for neurons, glia in a hierarchical manner / J Neurosci 19:10383~10389
Bonni A / 1997 / Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway / Science 278:477~483
Vaudry D / 2009 / Pituitary adenylate cyclase-activating polypeptide, its receptors:20 years after the discovery / Pharmacol Rev 61:283~357
Breckler M / 2011 / Rap-linked cAMP signaling Epac proteins: compartmentation, functioning, disease implications / Cell Signal 23:1257~1266
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