지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 296 - 301 (6page)
이용수
초록· 키워드
오류제보하기
Mitochondrial DNA (mtDNA) mutations are often observed in various cancer types. Although the correlation between mitochondrial dysfunction and cancer malignancy has been demonstrated by several studies, further research is required to elucidate the molecular mechanisms underlying accelerated tumor development and progression due to mitochondrial mutations. We generated an mtDNA-depleted cell line, ρ⁰, via long-term ethidium bromide treatment to define the molecular mechanisms of tumor malignancy induced by mitochondrial dysfunction. Mitochondrial dysfunction in ρ⁰ cells reduced drug-induced cell death and decreased the expression of pro-apoptotic proteins including p53. The p53 expression was reduced by activation of nuclear factor-κB that depended on elevated levels of free calcium in HCT116/ρ⁰ cells. Overall, these data provide a novel mechanism for tumor development and drug resistance due to mitochondrial dysfunction.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Scatena R / 2012 / Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation / Adv Exp Med Biol 942:287~308
엄지현 / 2017 / Emerging role of mitophagy in human diseases and physiology / BMB Reports 50(6):299~307
조봉기 / 2017 / CoMIC, the hidden dynamics of mitochondrial inner compartments / BMB Reports 50(12):597~598
Taanman JW / 1999 / The mitochondrial genome: structure, transcription, translation and replication / Biochim Biophys Acta 1410:103~123
Brandon M / 2006 / Mitochondrial mutations in cancer / Oncogene 25:4647~4662
엄지현 / 2017 / Emerging role of mitophagy in human diseases and physiology / BMB Reports 50(6):299~307
조봉기 / 2017 / CoMIC, the hidden dynamics of mitochondrial inner compartments / BMB Reports 50(12):597~598
Taanman JW / 1999 / The mitochondrial genome: structure, transcription, translation and replication / Biochim Biophys Acta 1410:103~123
Brandon M / 2006 / Mitochondrial mutations in cancer / Oncogene 25:4647~4662
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
The role of mitochondrial DNA mutation on neurodegenerative diseases
Experimental and Molecular Medicine
2015 .01
-
Molecular cross talkamongthecomponentsofthe regulatory machinery of mitochondrial structure and quality control
Experimental and Molecular Medicine
2020 .01
-
Emerging perspectives on mitochondrial dysfunction and inflammation in Alzheimer’s disease
BMB Reports
2020 .01
-
Techniques for investigating mitochondrial gene expression
BMB Reports
2020 .01
-
The coordinated regulation of mitochondrial structure and function by Drp1 for mitochondrial quality surveillance
BMB Reports
2019 .01
-
Application of Mitochondrial Transplantation Method in Various Indications
한국생물공학회 학술대회
2024 .09
-
The role of cell type-specific mitochondrial dysfunction in the pathogenesis of Alzheimer’s disease
BMB Reports
2019 .01
-
An experimental approach to study the function of mitochondria in cardiomyopathy
BMB Reports
2015 .01
-
Mitochondrial genome editing: strategies, challenges, and applications
BMB Reports
2024 .01
-
microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor
BMB Reports
2017 .01
-
Enhancing Activity of Natural Killer Cell by Mitochondrial Transfer
한국생물공학회 학술대회
2022 .04
-
Trends and prospects in mitochondrial genome editing
Experimental and Molecular Medicine
2023 .05
-
Mitochondrial Transplantation as a Novel Treatment Strategy for Tendinopathy
한국생물공학회 학술대회
2023 .04
-
Long-term depletion of cereblon induces mitochondrial dysfunction in cancer cells
BMB Reports
2021 .01
-
HSP70 attenuates compression-induced apoptosis of nucleus pulposus cells by suppressing mitochondrial fission via upregulating the expression of SIRT3
Experimental and Molecular Medicine
2022 .03
-
Mitochondrial dysfunction and Alzheimer’s disease: prospects for therapeutic intervention
BMB Reports
2020 .01
-
A mitochondrial proteome profile indicative of type 2 diabetes mellitus in skeletal muscles
Experimental and Molecular Medicine
2018 .01
-
Mitochondrial quality control in intervertebral disc degeneration
Experimental and Molecular Medicine
2021 .07
-
Mitochondrial noncoding RNA transport
BMB Reports
2017 .01
-
Migration and invasion of drug-resistant lung adenocarcinoma cells are dependent on mitochondrial activity
Experimental and Molecular Medicine
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0