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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 648 - 653 (6page)
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초록· 키워드
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Serine protease inhibitor Kazal type 1 (SPINK1) plays a role in protecting the pancreas against premature activation of trypsinogen and is involved in cancer progression. SPINK1 promoted LAC cells growth, migration, and invasion. Mechanistically, we found that SPINK1 promoted LAC cells migration and invasion via up-regulating matrix metalloproteinase 12 (MMP12). We observed that SPINK1 expression was only up-regulated in lung adenocarcinoma (LAC) tissues, and was an independent prognostic factor for poor survival. Our results indicate that SPINK1 might be a potential biomarker for LAC that promotes progression by MMP12.
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참고문헌 (26)
참고문헌 신청
Paci E / 2017 / Mortality, survival and incidence rates in the ITALUNG randomized lung cancer screening trial / Thorax 72:825~831
Parkin DM / 2002 / Global cancer statistics / CA Cancer J Clin 55:74~108
Molina JR / 2008 / Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship / Mayo Clin Proc 83:584~594
Stenman UH / 2002 / Tumor-associated trypsin inhibitor / Clin Chem 48:1206~1209
Itkonen O / 2014 / TATI as a biomarker / Clin Chim Acta 431:260~269
Parkin DM / 2002 / Global cancer statistics / CA Cancer J Clin 55:74~108
Molina JR / 2008 / Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship / Mayo Clin Proc 83:584~594
Stenman UH / 2002 / Tumor-associated trypsin inhibitor / Clin Chem 48:1206~1209
Itkonen O / 2014 / TATI as a biomarker / Clin Chim Acta 431:260~269
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